Structure of PDB 6uca Chain C Binding Site BS03

Receptor Information
>6uca Chain C (length=387) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PAPLCPHGPTFYACSACRDRKDCNFFQWEDEKLSGARLAAREAHNRRCQP
PLSRTQCVERYLKFIELPLTQRKFCQTCQQLLLPDDWGQHSEHQVLGNVS
ITQLRRPSQLLYPLENAATNAQYLFADRSCQFLVDLLSALGFRRVLCVGT
PRLHELIKLTASGDKKSNIKSLLLDIDFRYSQFYMEDSFCHYNMFNHHFF
DGKTALEVCRAFLQEDKGEGIIMVTDPPFGGLVEPLAITFKKLIAMWKEG
QSQDDSHKELPIFWIFPYFFESRICQFFPSFQMLDYQVDYDNHALYKRKQ
SPVRIFTNIPPNKIILPTEEGYRFCSPCQRYVSLENQHCELCNSCTSKDG
RKWNHCFLCKKCVKPSWIHCSICNHCAVPDHSCEGPK
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6uca Chain C Residue 1003 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6uca Structure and regulation of ZCCHC4 in m6A-methylation of 28S rRNA.
Resolution3.103 Å
Binding residue
(original residue number in PDB)		C125 C128 H140 H143
Binding residue
(residue number reindexed from 1)		C75 C78 H90 H93
Annotation score1
Enzymatic activity
Enzyme Commision number 2.1.1.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008168 methyltransferase activity
GO:0008270 zinc ion binding
GO:0008988 rRNA (adenine-N6-)-methyltransferase activity
Biological Process
GO:0031167 rRNA methylation
GO:0032259 methylation

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:6uca, PDBe:6uca, PDBj:6uca
PDBsum6uca
PubMed31695039
UniProtQ9H5U6|ZCHC4_HUMAN rRNA N6-adenosine-methyltransferase ZCCHC4 (Gene Name=ZCCHC4)

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