Structure of PDB 6oet Chain C Binding Site BS03

Receptor Information
>6oet Chain C (length=623) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HINKGGRPRQHLLSLTRRAQKHRLRELKIQVKEFADKEEGGDVKAVCLTL
FLLALRARNEHRQADELEAIMQGRGSGLQPAVCLAIRVNTFLSCSQYHKM
YRTVKAITGRQIFQPLHALRNAEKVLLPGYHPFEWQPPLKNVSSRTDVGI
IDGLSGLASSVDEYPVDTIAKRFRYDSALVSALMDMEEDILEGMRSQDLD
DYLNGPFTVVVKESCDGMGDVSEKHGSGPAVPEKAVRFSFTVMRITIEHG
SQNVKVFEEPKPNSELCCKPLCLMLADESDHETLTAILSPLIAEREAMKS
SELTLEMGGIPRTFKFIFRGTGYDEKLVREVEGLEASGSVYICTLCDTTR
LEASQNLVFHSITRSHAENLQRYEVWRSNPYHESVEELRDRVKGVSAKPF
IETVPSIDALHCDIGNAAEFYKIFQLEIGEVYKHPNASKEERKRWQATLD
KHLRKRMNLKPIMRMNGNFARKLMTQETVDAVCELIPSEERHEALRELMD
LYLKMKPVWRSSCPAKECPESLCQYSFNSQRFAELLSTKFKYRYEGKITN
YFHKTLAHVPEIIERDGSIGAWASEGNQSGNKLFRRFRKMNARQSKCYEM
EDVLKHHWLYTSKYLQKFMNAHN
Ligand information
>6oet Chain G (length=59) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ggtttttgtctggcttcacacttgatttgcatcactgtgcgccgcaggcc
agatccagg
Receptor-Ligand Complex Structure
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PDB6oet How mouse RAG recombinase avoids DNA transposition.
Resolution3.4 Å
Binding residue
(original residue number in PDB)		N443 L794 H795 R848 N850 G851 N852 Q962 K966 R969
Binding residue
(residue number reindexed from 1)		N59 L410 H411 R464 N466 G467 N468 Q578 K582 R585
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
3.1.-.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004519 endonuclease activity
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016740 transferase activity
GO:0042393 histone binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043565 sequence-specific DNA binding
GO:0046872 metal ion binding
GO:0061630 ubiquitin protein ligase activity
Biological Process
GO:0002250 adaptive immune response
GO:0002331 pre-B cell allelic exclusion
GO:0006310 DNA recombination
GO:0006325 chromatin organization
GO:0008542 visual learning
GO:0030183 B cell differentiation
GO:0033077 T cell differentiation in thymus
GO:0033151 V(D)J recombination
GO:0043029 T cell homeostasis
GO:0045580 regulation of T cell differentiation
GO:0045582 positive regulation of T cell differentiation
GO:0048538 thymus development
GO:0051865 protein autoubiquitination
GO:0070233 negative regulation of T cell apoptotic process
GO:0070244 negative regulation of thymocyte apoptotic process
GO:2000822 regulation of behavioral fear response
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6oet, PDBe:6oet, PDBj:6oet
PDBsum6oet
PubMed32015553
UniProtP15919|RAG1_MOUSE V(D)J recombination-activating protein 1 (Gene Name=Rag1)

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