Structure of PDB 6ksh Chain C Binding Site BS03

Receptor Information
>6ksh Chain C (length=490) Species: 36329 (Plasmodium falciparum 3D7) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GASMQSAANITLRQILEPNNVNLRSKKTHIVCTLGPACKSVETLVKLIDA
GMDICRFNFSHGSHEDHKEMFNNVLKAQELRPNCLLGMLLDTKGPEIRTG
FLKNKEVHLKEGSKLKLVTDYEFLGDETCIACSYKKLPQSVKPGNIILIA
DGSVSCKVLETHEDHVITEVLNSAVIGERKNMNLPNVKVDLPIISEKDKN
DILNFAIPMGCNFIAASFIQSADDVRLIRNLLGPRGRHIKIIPKIENIEG
IIHFDKILAESDGIMIARGDLGMEISPEKVFLAQKLMISKCNLQGKPIIT
ATQMLESMTKNPRPTRAEVTDVANAVLDGTDCVMLSGETAGGKFPVEAVT
IMSKICLEAEACIDYKLLYQSLVNAIETPISVQEAVARSAVETAESIQAS
LIIALTETGYTARLIAKYKPSCTILALSASDSTVKCLNVHRGVTCIKVGS
FQGTDIVIRNAIEIAKQRNMAKVGDSVIAIHNLMKVVQIE
Ligand information
Ligand IDOXL
InChIInChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2
InChIKeyMUBZPKHOEPUJKR-UHFFFAOYSA-L
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341		[O-]C(=O)C([O-])=O
OpenEye OEToolkits 1.5.0C(=O)(C(=O)[O-])[O-]
FormulaC2 O4
NameOXALATE ION
ChEMBL
DrugBank
ZINC
PDB chain6ksh Chain C Residue 605 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6ksh Pyruvate kinase from Plasmodium falciparum: Structural and kinetic insights into the allosteric mechanism.
Resolution2.6 Å
Binding residue
(original residue number in PDB)		K255 E257 A278 G280 D281 T313
Binding residue
(residue number reindexed from 1)		K244 E246 A267 G269 D270 T302
Annotation score2
Enzymatic activity
Catalytic site (original residue number in PDB) R67 R109 K255 T313
Catalytic site (residue number reindexed from 1) R56 R98 K244 T302
Enzyme Commision number 2.7.1.40: pyruvate kinase.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003824 catalytic activity
GO:0004743 pyruvate kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0030955 potassium ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006096 glycolytic process
GO:0016310 phosphorylation
GO:0051289 protein homotetramerization
Cellular Component
GO:0005737 cytoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6ksh, PDBe:6ksh, PDBj:6ksh
PDBsum6ksh
PubMed32878705
UniProtC6KTA4

[Back to BioLiP]