Structure of PDB 6jcy Chain C Binding Site BS03

Receptor Information
>6jcy Chain C (length=1139) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RPQSSSNNSVPGAPNRVSFAKLREPLEVPGLLDVQTDSFEWLIGSPRWRE
SAAERGDVNPVGGLEEVLYELSPIEDFSGSMSLSFSDPRFDDVKAPVDEC
KDKDMTYAAPLFVTAEFINNNTGEIKSQTVFMGDFPMMTEKGTFIINGTE
RVVVSQLVRSPGVYFDETIDKSTDKTLHSVKVIPSRGAWLEFDVDKRDTV
GVRIDRKRRQPVTVLLKALGWTSEQIVERFGFSEIMRSTLEKDNTVGTDE
ALLDIYRKLRPGEPPTKESAQTLLENLFFKEKRYDLARVGRYKVNKKLGL
HVGEPITSSTLTEEDVVATIEYLVRLHEGQTTMTVPGGVEVPVETDDIDH
FGNRRLRTVGELIQNQIRVGMSRMERVVRERMTTQDVEAITPQTLINIRP
VVAAIKEFFGTSQLSQFMDQNNPLSGLTHKRRLSALGPGGLSRERAGLEV
RDVHPSHYGRMCPIETPEGPNIGLIGSLSVYARVNPFGFIETPYRKVVDG
VVSDEIVYLTADEEDRHVVAQANSPIDADGRFVEPRVLVRRKAGEVEYVP
SSEVDYMDVSPRQMVSVATAMIPFLEHDDANRALMGANMQRQAVPLVRSE
APLVGTGMELRAAIDAGDVVVAEESGVIEEVSADYITVMHDNGTRRTYRM
RKFARSNHGTCANQCPIVDAGDRVEAGQVIADGPCTDDGEMALGKNLLVA
IMPWEGHNYEDAIILSNRLVEEDVLTSIHIEEHEIDARDTKLGAEEITRD
IPNISDEVLADLDERGIVRIGAEVRDGDILVGKVTPKGETELTPEERLLR
AIFGEKAREVRDTSLKVPHGESGKVIGIRVFSREDEDELPAGVNELVRVY
VAQKRKISDGDKLAGRHGNKGVIGKILPVEDMPFLADGTPVDIILNTHGV
PRRMNIGQILETHLGWCAHSGWKVDAAKGVPDWAARLPDELLEAQPNAIV
STPVFDGAQEAELQGLLSCTLPNRDGDVLVDADGKAMLFDGRSGEPFPYP
VTVGYMYIMKLHHLVDDKIHARSTGPYSMITQQPLGGKAQFGGQRFGEME
CWAMQAYGAAYTLQELLTIKSDDTVGRVKVYEAIVKGENIPEPGIPESFK
VLLKELQSLCLNVEVLSSDGAAIELREGEDEDLERAAAN
Ligand information
Receptor-Ligand Complex Structure
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PDB6jcy Structures and mechanism of transcription initiation by bacterial ECF factors.
Resolution3.106 Å
Binding residue
(original residue number in PDB)		R465 N493 Q614 K884 K892 H1035
Binding residue
(residue number reindexed from 1)		R443 N471 Q592 K862 K870 H1013
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0005515 protein binding
GO:0016779 nucleotidyltransferase activity
GO:0032549 ribonucleoside binding
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0046677 response to antibiotic
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0009274 peptidoglycan-based cell wall

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6jcy, PDBe:6jcy, PDBj:6jcy
PDBsum6jcy
PubMed31131408
UniProtP9WGY9|RPOB_MYCTU DNA-directed RNA polymerase subunit beta (Gene Name=rpoB)

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