Structure of PDB 6e8f Chain C Binding Site BS03

Receptor Information

>6e8f Chain C (length=333) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

PMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN
IRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKA
EQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDS
LNLTSPLRIVALDKDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGIT
RYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFP
EISPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPG
VEMIVGRTYALTVQAADNAPPAERRNSICTVYI

Ligand information

Ligand ID

InChI

InChI=1S/Ca/q+2

InChIKey

BHPQYMZQTOCNFJ-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Ca++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Ca+2]

Formula

Name

CALCIUM ION

PDB chain

6e8f Chain C Residue 703 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6e8f Structural determinants of protocadherin-15 mechanics and function in hearing and balance perception.
Resolution	2.99 Å
Binding residue (original residue number in PDB)	N489 N491 D521 D523 N527 D573
Binding residue (residue number reindexed from 1)	N243 N245 D265 D267 N271 D317
Annotation score	4

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0005509	calcium ion binding

	Biological Process
GO:0007155	cell adhesion
GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules

	Cellular Component
GO:0005886	plasma membrane
GO:0016020	membrane

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Biological Process

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Cellular Component

External links

PDB	RCSB:6e8f, PDBe:6e8f, PDBj:6e8f
PDBsum	6e8f
PubMed	32963095
UniProt	Q96QU1\|PCD15_HUMAN Protocadherin-15 (Gene Name=PCDH15)

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