Structure of PDB 6dbq Chain C Binding Site BS03

Receptor Information
>6dbq Chain C (length=616) Species: 7955,83333 [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GGRPRQHLLSLTRRAQKHRLRDLKNQVKTFAEKEEGGDVKSVCLTLFLLA
LRAGNEHKQADELEAMMQGRGFGLHPAVCLAIRVNTFLSCSQYHKMYRTV
KATSGRQIFQPLHTLRNAEKELLPGFHQFEWQPALKNVSTSWDVGIIDGL
SGWTVSVDDVPADTISRRFRYDVALVSALKDLEEDIMEGLRERALDDSMC
TSGFTVVVKESCDGMGDVSEKVPEKAVRFSFTIMSISIRLEGEDDGITIF
QEQKPNSELSCRPLCLMFVDESDHETLTAILGPVVAERKAMMESRLIISV
GGLLRSFRFFFRGTGYDEKMVREMEGLEASGSTYICTLCDSTRAEASQNM
VLHSITRSHDENLERYEIWRKNPFSESADELRDRVKGVSAKPFMETQPTL
DALHCDIGNATEFYKIFQDEIGEVYQKPNPSREERRRWRSTLDKQLRKKM
KLKPVMRMNGNYARRLMTREAVEAVCELVPSEERREALLKLMDLYLQMKP
VWRSTCPSRDCPDQLCQYSYNSQQFADLLSSMFKYRYDGKITNYLHKTLA
HVPEIVERDGSIGAWASEGNESGNKLFRRFRKMNARQSKTFELEDILKHH
WLYTSKYLQKFMEAHK
Ligand information
>6dbq Chain G (length=61) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gatctggcctgtcttacacagtggtagtactccactgtctggctgtacaa
aaaccctgcag
Receptor-Ligand Complex Structure
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PDB6dbq DNA melting initiates the RAG catalytic pathway.
Resolution4.22 Å
Binding residue
(original residue number in PDB)		A460 N462 H464 D620 M622 G623 D730 E731 H817 R845 M869 R870 T955 N956 E984 R991 R992
Binding residue
(residue number reindexed from 1)		A53 N55 H57 D213 M215 G216 D317 E318 H404 R432 M456 R457 T542 N543 E571 R578 R579
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
3.1.-.-
Gene Ontology
Molecular Function
GO:0004519 endonuclease activity
GO:0005515 protein binding
GO:0015144 carbohydrate transmembrane transporter activity
GO:0043565 sequence-specific DNA binding
GO:0046872 metal ion binding
GO:0061630 ubiquitin protein ligase activity
GO:1901982 maltose binding
Biological Process
GO:0006974 DNA damage response
GO:0008643 carbohydrate transport
GO:0015768 maltose transport
GO:0033151 V(D)J recombination
GO:0034219 carbohydrate transmembrane transport
GO:0034289 detection of maltose stimulus
GO:0042956 maltodextrin transmembrane transport
GO:0055085 transmembrane transport
GO:0060326 cell chemotaxis
Cellular Component
GO:0016020 membrane
GO:0030288 outer membrane-bounded periplasmic space
GO:0042597 periplasmic space
GO:0043190 ATP-binding cassette (ABC) transporter complex
GO:0055052 ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
GO:1990060 maltose transport complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6dbq, PDBe:6dbq, PDBj:6dbq
PDBsum6dbq
PubMed30061602
UniProtO13033|RAG1_DANRE V(D)J recombination-activating protein 1 (Gene Name=rag1);
P0AEX9|MALE_ECOLI Maltose/maltodextrin-binding periplasmic protein (Gene Name=malE)

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