Structure of PDB 5xoj Chain C Binding Site BS03

Receptor Information
>5xoj Chain C (length=999) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DLDIALLDQVVSTFYQGSGVQQKQAQEILTKFQDNPDAWQKADQILQFST
NPQSKFIALSILDKLITRKWKLLPNDHRIGIRNFVVGMIISMCQDDEVFK
TQKNLINKSDLTLVQILKQEWPQNWPEFIPELIGSSSSSVNVCENNMIVL
KLLSEEVFDFSAEQMTQAKALHLKNSMSKEFEQIFKLCFQVLEQGSSSSL
IVATLESLLRYLHWIPYRYIYETNILELLSTKFMTSPDTRAITLKCLTEV
SNLQDNDLIKRQTVLFFQNTLQQIATSVMPVTADLKATYANANGNDQSFL
QDLAMFLTTYLARNRALLESDESLRELLLNAHQYLIQLSKIEERELFKTT
LDYWHNLVADLFYEPLKKHIYEEICSQLRLVIIENMVRPEEVLVVENDEG
EIVREFVKESDTIQLYKSEREVLVYLTHLNVIDTEEIMISKLARQIDGSE
WSWHNINTLSWAIGSISGTMSEDTEKRFVVTVIKDLLDLTVKKRGKDNKA
VVASDIMYVVGQYPRFLKAHWNFLRTVILKLFEFMHETHEGVQDMACDTF
IKIVQKCKYHFVIQQPRESEPFIQTIIRDIQKTTADLQPQQVHTFYKACG
IIISEERSVAERNRLLSDLMQLPNMAWDTIVEQSTANPTLLLDSETVKII
ANIIKTNVAVCTSMGADFYPQLGHIYYNMLQLYRAVSSMISAQVAAEGLI
ATKTPKVRGLRTIKKEILKLVETYISKARNLDDVVKVLVEPLLNAVLEDY
MNNVPDARDAEVLNCMTTVVEKVGHMIPQGVILILQSVFECTLDMINKDF
TEYPEHRVEFYKLLKVINEKSFAAFLELPPAAFKLFVDAICWAFKHNNRD
VEVNGLQIALDLVKNIERMGNVPFANEFHKNYFFIFVSETFFVLTDSDHK
SGFSKQALLLMKLISLVYDNKISVPLYQGTSNQVYLSQYLANMLSNAFPH
LTSEQIASFLSALTKQYKDLVVFKGTLRDFLVQIKEVGGDPTDYLFAED
Ligand information
>5xoj Chain F (length=9) Species: 764102 (Saccharomyces cerevisiae FostersB) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
SAFGAPAFG
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5xoj Crystal structure of the Xpo1p nuclear export complex bound to the SxFG/PxFG repeats of the nucleoporin Nup42p
Resolution2.2 Å
Binding residue
(original residue number in PDB)		N793 E797 M800 L832 Q835 S836 F838 E839 L877 A881
Binding residue
(residue number reindexed from 1)		N744 E748 M751 L783 Q786 S787 F789 E790 L828 A832
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005049 nuclear export signal receptor activity
GO:0005515 protein binding
GO:0017070 U6 snRNA binding
GO:0030619 U1 snRNA binding
GO:0030620 U2 snRNA binding
GO:0030621 U4 snRNA binding
GO:0030623 U5 snRNA binding
GO:0031267 small GTPase binding
GO:0061608 nuclear import signal receptor activity
Biological Process
GO:0000055 ribosomal large subunit export from nucleus
GO:0000056 ribosomal small subunit export from nucleus
GO:0006406 mRNA export from nucleus
GO:0006409 tRNA export from nucleus
GO:0006611 protein export from nucleus
GO:0006886 intracellular protein transport
GO:0015031 protein transport
GO:0034501 protein localization to kinetochore
GO:0051168 nuclear export
GO:0051170 import into nucleus
GO:0071528 tRNA re-export from nucleus
Cellular Component
GO:0000776 kinetochore
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005816 spindle pole body
GO:0048471 perinuclear region of cytoplasm

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5xoj, PDBe:5xoj, PDBj:5xoj
PDBsum5xoj
PubMed28791779
UniProtP30822|XPO1_YEAST Exportin-1 (Gene Name=CRM1)

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