Structure of PDB 5wrj Chain C Binding Site BS03

Receptor Information
>5wrj Chain C (length=273) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AYHKDMPLIFIGGVPRSGTTLMRAMLDAHPDIRCGEETRVIPRILALKQM
WSRSSKEKIRLDEAGVTDEVLDSAMQAFLLEIIVKHGEPAPYLCNKDPFA
LKSLTYLSRLFPNAKFLLMVRDGRASVHSMISRKVTIAGFDLNSYRDCLT
KWNRAIETMYNQCMEVGYKKCMLVHYEQLVLHPERWMRTLLKFLQIPWNH
SVLHHEEMIGKAGGVSLSKVERSTDQVIKPVNVGALSKWVGKIPPDVLQD
MAVIAPMLAKLGYDPYANPPNYG
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain5wrj Chain C Residue 402 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5wrj Structural basis for the broad substrate specificity of the human tyrosylprotein sulfotransferase-1.
Resolution2.31 Å
Binding residue
(original residue number in PDB)		D90 H92 P93 I95 G276
Binding residue
(residue number reindexed from 1)		D27 H29 P30 I32 G213
Annotation score1
Enzymatic activity
Enzyme Commision number 2.8.2.20: protein-tyrosine sulfotransferase.
Gene Ontology
Molecular Function
GO:0008476 protein-tyrosine sulfotransferase activity
Biological Process
GO:0006478 peptidyl-tyrosine sulfation

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Molecular Function
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Biological Process
External links
PDB RCSB:5wrj, PDBe:5wrj, PDBj:5wrj
PDBsum5wrj
PubMed28821720
UniProtO60507|TPST1_HUMAN Protein-tyrosine sulfotransferase 1 (Gene Name=TPST1)

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