Structure of PDB 5oes Chain C Binding Site BS03

Receptor Information

>5oes Chain C (length=447) Species: 4113 (Solanum tuberosum)

IVDPHDIDPKLVQKLANDALVWCSLRGLLVGDRNSERSGTVPGVDMVHAP
VALIPMSFPESHWKQACEVAPIFNELVDRVSQDGEFLQQSLSRTRKVDPF
TSRLLEIHSKMLEINKIEEIRLGLHRSDYMLDEQTKLLLQIELNTISSSF
PGLSCLVSELHRSLLQQYREDIASDPNRIPANNAVNQFAEALAKAWNEYG
DPRAVIMFAVQAEERNMYDQHWLSASLRERHQVTTIRKTLAEIDALGELQ
QDGTLVVDGQAVAVIYFRAGYAPSDYNSESEWKARLLMEQSRAVKCPSIS
YHLAGSKKIQQELAKPNVLERFLENKDDIAKLRKCFAGLWSLDESDIVKD
AIDRPELYVMKPQNNIYGEDVRDALLKLYILMQRIFPKISHSILMREGIS
HKEQTISELGIYGTYLRNKTEVVINQQAGYLMRTKVSFAVLDSIYLV

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 5oes Chain C Residue 504

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5oes Effector gene birth in plant parasitic nematodes: Neofunctionalization of a housekeeping glutathione synthetase gene.
• Resolution: 2.48 Å
• Binding residue (original residue number in PDB): D139 E153 E434
• Binding residue (residue number reindexed from 1): D128 E142 E408
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 6.3.2.3: glutathione synthase.

Gene Ontology

Molecular Function

• GO:0000287 magnesium ion binding
• GO:0004363 glutathione synthase activity
• GO:0005524 ATP binding
• GO:0016874 ligase activity
• GO:0043295 glutathione binding
• GO:0046872 metal ion binding

Biological Process

• GO:0006750 glutathione biosynthetic process

Cellular Component

• GO:0005829 cytosol

External links

• PDB: RCSB:5oes, PDBe:5oes, PDBj:5oes
• PDBsum: 5oes
• PubMed: 29641602
• UniProt: M1CSC4