Structure of PDB 5mwf Chain C Binding Site BS03

Receptor Information
>5mwf Chain C (length=262) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MGYFELQLSALRNVNGELLSGACCDGDGRCGHDECDTYVRVCLKEYQAKV
TPTGPCSYGHGATPVLGGNSFYLPPAGDPGLVVIPFQFAWPRSFTLIVEA
WDWDNDTTPNEELLIERVSHAGMINPEDRWKSLHFSGHVAHLELQIRVRC
DENYYSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKECKEAVCKQG
CNLLHGGCTVPGECRCSYGWQGRFCDECVPYPGCVHGSCVEPWQCNCETN
WGGLLCDKDLNG
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain5mwf Chain C Residue 406 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5mwf Structural and functional dissection of the interplay between lipid and Notch binding by human Notch ligands.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		D51 D68 D150 W151 D152
Binding residue
(residue number reindexed from 1)		D25 D36 D102 W103 D104
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0007154 cell communication
GO:0007219 Notch signaling pathway
GO:0007275 multicellular organism development
Cellular Component
GO:0016020 membrane

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Biological Process
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Cellular Component
External links
PDB RCSB:5mwf, PDBe:5mwf, PDBj:5mwf
PDBsum5mwf
PubMed28572448
UniProtQ9Y219|JAG2_HUMAN Protein jagged-2 (Gene Name=JAG2)

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