Structure of PDB 5gt0 Chain C Binding Site BS03

Receptor Information

>5gt0 Chain C (length=106) Species: 9606 (Homo sapiens)

SKSRSSRAGLQFPVGRIHRLLRKGNYAERIGAGAPVYLAAVLEYLTAEIL
ELAGNASRDNKKTRIIPRHLQLAIRNDEELNKLLGGVTIAQGGVLPNIQA
VLLPKK

Ligand information

• Ligand ID: MN
• InChI: InChI=1S/Mn/q+2
• InChIKey: WAEMQWOKJMHJLA-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mn+2]
  CACTVS 3.341: [Mn++]
• Formula: Mn
• Name: MANGANESE (II) ION
• DrugBank: DB06757
• PDB chain: 5gt0 Chain C Residue 201

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5gt0 Structural analyses of the nucleosome complexes with human testis-specific histone variants, hTh2a and hTh2b
• Resolution: 2.82 Å
• Binding residue (original residue number in PDB): G44 A45 G46
• Binding residue (residue number reindexed from 1): G31 A32 G33
• Annotation score: 4

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0030527 structural constituent of chromatin
• GO:0031492 nucleosomal DNA binding
• GO:0046982 protein heterodimerization activity

Biological Process

• GO:0006325 chromatin organization
• GO:0031507 heterochromatin formation

Cellular Component

• GO:0000781 chromosome, telomeric region
• GO:0000786 nucleosome
• GO:0001674 female germ cell nucleus
• GO:0005634 nucleus
• GO:0005694 chromosome
• GO:0070062 extracellular exosome

External links

• PDB: RCSB:5gt0, PDBe:5gt0, PDBj:5gt0
• PDBsum: 5gt0
• PubMed: 27992841
• UniProt: Q96QV6|H2A1A_HUMAN Histone H2A type 1-A (Gene Name=H2AC1)