Structure of PDB 5f1c Chain C Binding Site BS03

Receptor Information
>5f1c Chain C (length=344) Species: 34609 (Amblyomma maculatum) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VLNRLIQLLILGYIIGYVIIYQKGYQQFSTFNAATTTKVKGVVSTKNLSD
DAFYPFLSDKTVYKRVWDIADIVVPPEESNQFFVTTNLIITPSQEIKTCP
EDPSIKEAHCKSENDTTSCTAGKSIMIGNGVMTGRCVQAAKPQETLHVCE
ISGWCPVEQDYGPLKDGTPLLSDVQNFTVLIKNYIEFSLFHVRRSNLHDI
ENSTYLKYCRYHPEKDPHCPVFRIGDMVDAAGEDFDDVAAKGGVIQVLIS
WDCNLDYDVKYCIPNYSFLRLDDPKTVLAKGWNFRYPKYYNEKERSLVKA
YGITFVILVQGRAGKLSPIPIAINIGSGLGLMVVATVLCDLVVL
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5f1c Chain C Residue 404 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5f1c Structural Insights into Divalent Cation Modulations of ATP-Gated P2X Receptor Channels
Resolution2.9 Å
Binding residue
(original residue number in PDB)		E141 H175
Binding residue
(residue number reindexed from 1)		E113 H147
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0001614 purinergic nucleotide receptor activity
GO:0004931 extracellularly ATP-gated monoatomic cation channel activity
GO:0005524 ATP binding
GO:0015267 channel activity
GO:0046872 metal ion binding
Biological Process
GO:0006811 monoatomic ion transport
GO:0007165 signal transduction
GO:0033198 response to ATP
GO:0035590 purinergic nucleotide receptor signaling pathway
GO:0060079 excitatory postsynaptic potential
GO:0070588 calcium ion transmembrane transport
GO:0098655 monoatomic cation transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0098794 postsynapse

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5f1c, PDBe:5f1c, PDBj:5f1c
PDBsum5f1c
PubMed26804916
UniProtG3MM57

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