Structure of PDB 5exh Chain C Binding Site BS03

Receptor Information
>5exh Chain C (length=45) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KKRKRCGTCDPCRRLENCGSCTSCTNRRTHQICKLRKCEVLKKKA
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5exh Chain C Residue 201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5exh Tet3 Reads 5-Carboxylcytosine through Its CXXC Domain and Is a Potential Guardian against Neurodegeneration.
Resolution1.3 Å
Binding residue
(original residue number in PDB)		C57 C60 C63 C89
Binding residue
(residue number reindexed from 1)		C6 C9 C12 C38
Annotation score1
Enzymatic activity
Enzyme Commision number 1.14.11.80: methylcytosine dioxygenase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0008270 zinc ion binding

View graph for
Molecular Function
External links
PDB RCSB:5exh, PDBe:5exh, PDBj:5exh
PDBsum5exh
PubMed26774490
UniProtQ8BG87|TET3_MOUSE Methylcytosine dioxygenase TET3 (Gene Name=Tet3)

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