Structure of PDB 4zi6 Chain C Binding Site BS03

Receptor Information
>4zi6 Chain C (length=481) Species: 85962 (Helicobacter pylori 26695) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MLKIKLEKTTFENAKAECSLVFIINKDFSHAWVKNKELLETFKYEGEGVF
LDQENKILYAGVKEDDVHLLRESACLAVRTLKKLAFKSVKVGVYTNALLE
NLKALFLGLKLGLYEYDTFKSNKKESVLKEAIVALELHKSLEKSAKEALK
YAEIMTESLNIVKDLVNTPPMIGTPVYMAEVAQKVAKENHLEIHVHDEKF
LEEKKMNAFLAVNKASLSVNPPRLIHLVYKPKKAKKKIALVGKGLTYDCG
GLSLKPADYMVTMKADKGGGSAVIGLLNALAKLGVEAEVHGIIGATENMI
GPAAYKPDDILISKEGKSIEVRNTDAEGRLVLADCLSYAQDLNPDVIVDF
ATLTGACVVGLGEFTSAIMGHNEELKNLFETSGLESGELLAKLPFNRHLK
KLIESKIADVCNISSSRYGGAITAGLFLNEFIRDEFKDKWLHIDIAGPAY
VEKEWDVNSFGASGAGVRACTAFVEELLKKA
Ligand information
Ligand IDBCT
InChIInChI=1S/CH2O3/c2-1(3)4/h(H2,2,3,4)/p-1
InChIKeyBVKZGUZCCUSVTD-UHFFFAOYSA-M
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(=O)(O)[O-]
CACTVS 3.341OC([O-])=O
ACDLabs 10.04[O-]C(=O)O
FormulaC H O3
NameBICARBONATE ION
ChEMBL
DrugBank
ZINC
PDB chain4zi6 Chain C Residue 503 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4zi6 Structural basis for substrate specificity of Helicobacter pylori M17 aminopeptidase.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		A341 E342 G343 R344 L368
Binding residue
(residue number reindexed from 1)		A326 E327 G328 R329 L353
Annotation score4
Enzymatic activity
Catalytic site (original residue number in PDB) K270 R344
Catalytic site (residue number reindexed from 1) K255 R329
Enzyme Commision number 3.4.11.1: leucyl aminopeptidase.
3.4.11.10: bacterial leucyl aminopeptidase.
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0008235 metalloexopeptidase activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
GO:0070006 metalloaminopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0019538 protein metabolic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4zi6, PDBe:4zi6, PDBj:4zi6
PDBsum4zi6
PubMed26616008
UniProtO25294|AMPA_HELPY Cytosol aminopeptidase (Gene Name=pepA)

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