Structure of PDB 4pfp Chain C Binding Site BS03

Receptor Information
>4pfp Chain C (length=766) Species: 9823 (Sus scrofa) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KPVWAPHPTDGFQVGNIVDIGPDSLTIEPLNQKGKTFLALINQVFPAEED
SKKDVEDNCSLMYLNEATLLHNIKVRYSKDRIYTYVANILIAVNPYFDIP
KIYSSETIKSYQGKSLGTMPPHVFAIADKAFRDMKVLKLSQSIIVSGESG
AGKTENTKFVLRYLTESYGTGQDIDDRIVEANPLLEAFGNAKTVRNNNSS
RFGKFVEIHFNEKSSVVGGFVSHYLLEKSRICVQGKEERNYHIFYRLCAG
ASEDIRERLHLSSPDNFRYLNRGCTRYFANKETDKQILQNRKSPEYLKAG
SLKDPLLDDHGDFIRMCTAMKKIGLDDEEKLDLFRVVAGVLHLGNIDFEE
AGSTSGGCNLKNKSTQALEYCAELLGLDQDDLRVSLTTRVMLTGTVIKVP
LKVEQANNARDALAKTVYSHLFDHVVNRVNQCFPFETSSYFIGVLDIAGF
EYFEHNSFEQFCINYCNEKLQQFFNERILKEEQELYQKEGLGVNEVHYVD
NQDCIDLIEARLVGILDILDEENRLPQPSDQHFTSAVHQKHKDHFRLSIP
RKSKLAIHRNIRDDEGFIIRHFAGAVCYETTQFVEKNNDALHMSLESLIC
ESRDKFIRELFEGKLSFISVGNKFKTQLNLLLDKLRSTGASFIRCIKPNL
KMTSHHFEGAQILSQLQCSGMVSVLDLMQGGFPSRASFHELYNMYKKYMP
DKLARLDPRLFCKALFKALGLNEIDYKFGLTKVFFRPGKFAEFDQIMKSD
PDHLAELVKRVNHWLI
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain4pfp Chain C Residue 803 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4pfp How actin initiates the motor activity of Myosin.
Resolution2.32 Å
Binding residue
(original residue number in PDB)		T158 S204
Binding residue
(residue number reindexed from 1)		T154 S200
Annotation score4
Enzymatic activity
Catalytic site (original residue number in PDB) S153 T158 S203 S204 G459 E461
Catalytic site (residue number reindexed from 1) S149 T154 S199 S200 G449 E451
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003774 cytoskeletal motor activity
GO:0005524 ATP binding
GO:0051015 actin filament binding
Cellular Component
GO:0016459 myosin complex

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:4pfp, PDBe:4pfp, PDBj:4pfp
PDBsum4pfp
PubMed25936506
UniProtF1RQI7

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