Structure of PDB 4p0s Chain C Binding Site BS03

Receptor Information
>4p0s Chain C (length=275) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QQQPLELRPGEYRVLLCVDIGETRGPELLRELQRLHVTHTVRKLHVGDFV
WVAQETNPRDPANPGELVLDHIVERKRLDDLCSSIIDGRFREQKFRLKRC
GLERRVYLVEEHGSVHNLSLPESTLLQAVTNTQVIDGFFVKRTADIKESA
AYLALLTRGLQRLYQGHTLRSRPWGTPGPNPLCSLLTFSDFNAGAREVFA
RQLMQVRGVSGEKAAALVDRYSTPASLLAAYDACATPKEQETLLSTIKCG
RLQRNLGPALSRTLSQLYCSYGPLT
Ligand information
Receptor-Ligand Complex Structure
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PDB4p0s Crystal structures of the structure-selective nuclease Mus81-Eme1 bound to flap DNA substrates.
Resolution6.0 Å
Binding residue
(original residue number in PDB)		D274 G276 E277 K302 L303 R355
Binding residue
(residue number reindexed from 1)		D19 G21 E22 K43 L44 R96
Enzymatic activity
Enzyme Commision number 3.1.22.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004518 nuclease activity
GO:0008821 crossover junction DNA endonuclease activity
Biological Process
GO:0006302 double-strand break repair
GO:0006308 DNA catabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4p0s, PDBe:4p0s, PDBj:4p0s
PDBsum4p0s
PubMed24733841
UniProtQ96NY9|MUS81_HUMAN Crossover junction endonuclease MUS81 (Gene Name=MUS81)

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