Structure of PDB 4ghf Chain C Binding Site BS03

Receptor Information

>4ghf Chain C (length=351) Species: 47914 (Brevibacterium fuscum) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

EIPKPVAPAPDILRCAYAELVVTDLAKSRNFYVDVLGLHVSYEDENQIYL
RSFEEFIHHNLVLTKGPVAALKAMAFRVRTPEDVDKAEAYYQELGCRTER
RKDGFVKGIGDALRVEDPLGFPYEFFFETTHVERLHMRYDLYSAGELVRL
DHFNQVTPDVPRGRKYLEDLGFRVTEDIQDDEGTTYAAWMHRKGTVHDTA
LTGGNGPRLHHVAFSTHEKHNIIQICDKMGALRISDRIERGPGRHGVSNA
FYLFILDPDNHRIEIYTQDYYTGDPDNPTITWNVHDNQRRDWWGNPVVPS
WYTEASKVLDLDGNVQEIIERTDDSELEVTIGADGFSFTRAGDEDGSYHG
Q

Ligand information

InChI=1S/O2/c1-2

MYMOFIZGZYHOMD-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341 OpenEye OEToolkits 1.5.0	O=O

Formula

Name

OXYGEN MOLECULE

PDB chain

4ghf Chain C Residue 405 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	4ghf Structural basis for the role of tyrosine 257 of homoprotocatechuate 2,3-dioxygenase in substrate and oxygen activation.
Resolution	1.67 Å
Binding residue (original residue number in PDB)	H155 N157 W192 H200 H214
Binding residue (residue number reindexed from 1)	H152 N154 W189 H197 H211
Annotation score	5

Enzymatic activity

Catalytic site (original residue number in PDB)	H155 H200 H214 H248 F257 E267
Catalytic site (residue number reindexed from 1)	H152 H197 H211 H245 F254 E264
Enzyme Commision number	1.13.11.15: 3,4-dihydroxyphenylacetate 2,3-dioxygenase.

Gene Ontology

	Molecular Function
GO:0046872	metal ion binding
GO:0051213	dioxygenase activity

View graph for
Molecular Function

External links

PDB	RCSB:4ghf, PDBe:4ghf, PDBj:4ghf
PDBsum	4ghf
PubMed	23066739
UniProt	Q45135

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