Structure of PDB 4fo7 Chain C Binding Site BS03

Receptor Information

>4fo7 Chain C (length=258) Species: 208964 (Pseudomonas aeruginosa PAO1)

TVTIKTPDDIEKMRIAGRLAAEVLEMIGEHIKPGVTTEELDRICHDYIVN
EQKAIPAPLNYKGFPKSICTSINHVVCHGIPNEKPLKEGDILNVDITVIK
DGYHGDTSKMFLVGKTPEWADRLCQITQECMYKGISVVRPGAHLGDIGEI
IQKHAEKNGFSVVREYCGHGIGKVFHEEPQVLHYGRAGTGIELKEGMIFT
IEPMINQGRPETRLLGDGWTAITKDRKLSAQWEHTVLVTADGYEILTLRN
DETFPRTS

Ligand information

• Ligand ID: MN
• InChI: InChI=1S/Mn/q+2
• InChIKey: WAEMQWOKJMHJLA-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mn+2]
  CACTVS 3.341: [Mn++]
• Formula: Mn
• Name: MANGANESE (II) ION
• DrugBank: DB06757
• PDB chain: 4fo7 Chain C Residue 303

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4fo7 Methionine excision captured by the structures of a methionine aminopeptidase
• Resolution: 1.8 Å
• Binding residue (original residue number in PDB): N74 V76 S230
• Binding residue (residue number reindexed from 1): N73 V75 S229
• Annotation score: 4

Enzymatic activity

• Catalytic site (original residue number in PDB): D96 D107 H170 H177 E203 E234
• Catalytic site (residue number reindexed from 1): D95 D106 H169 H176 E202 E233
• Enzyme Commision number: 3.4.11.18: methionyl aminopeptidase.

Gene Ontology

Molecular Function

• GO:0004177 aminopeptidase activity
• GO:0004239 initiator methionyl aminopeptidase activity
• GO:0008235 metalloexopeptidase activity
• GO:0046872 metal ion binding
• GO:0046914 transition metal ion binding
• GO:0070006 metalloaminopeptidase activity

Biological Process

• GO:0006508 proteolysis

Cellular Component

• GO:0005829 cytosol

External links

• PDB: RCSB:4fo7, PDBe:4fo7, PDBj:4fo7
• PDBsum: 4fo7
• UniProt: Q9HXY1