Structure of PDB 3v79 Chain C Binding Site BS03

Receptor Information

>3v79 Chain C (length=424) Species: 9606 (Homo sapiens)

RPPPKRLTREAMRNYLKERGDQTVLILHAKVAQKSYGNEKRFFCPPPCVY
LMGSGWKKKKEQMERDGCSEQESQPCAFIGIGNSDQEMQQLNLEGKNYCT
AKTLYISDSDKRKHFMLSVKMFYGNSDDIGVFLSKRIKVISKPSKKKQSL
KNADLCIASGTKVALFNRLRSQTVSTRYLHVEGGNFHASSQQWGAFFIHL
LDDDESEGEEFTVRDGYIHYGQTVKLVCSVTGMALPRLIIRKVDKQTALL
DADDPVSQLHKCAFYLKDTERMYLCLSQERIIQFQATPCPKEPNKEMIND
GASWTIISTDKAEYTFYEGMGPVLAPVTPVPVVESLQLNGGGDVAMLELT
GQNFTPNLRVWFGDVEAETMYRCGESMLCVVPDISAFREGWRWVRQPVQV
PVTLVRNDGIIYSTSLTFTYTPEP

Ligand information

>3v79 Chain R (length=19) Species: 9606 (Homo sapiens)

KRRRQHGQLWFPEGFKVSE

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3v79 Conformational Locking upon Cooperative Assembly of Notch Transcription Complexes.
• Resolution: 3.85 Å
• Binding residue (original residue number in PDB): N195 F196 H209 E219 E220 F221 T222 V223 R224 D225 M243 A244 P246 K277 T279 M282 Q293
• Binding residue (residue number reindexed from 1): N185 F186 H199 E209 E210 F211 T212 V213 R214 D215 M233 A234 P236 K267 T269 M272 Q283

Gene Ontology

Molecular Function

• GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
• GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
• GO:0003677 DNA binding
• GO:0003700 DNA-binding transcription factor activity

Biological Process

• GO:0006355 regulation of DNA-templated transcription
• GO:0006357 regulation of transcription by RNA polymerase II

Cellular Component

• GO:0005634 nucleus

External links

• PDB: RCSB:3v79, PDBe:3v79, PDBj:3v79
• PDBsum: 3v79
• PubMed: 22325781
• UniProt: Q06330|SUH_HUMAN Recombining binding protein suppressor of hairless (Gene Name=RBPJ)