Structure of PDB 3tht Chain C Binding Site BS03

Receptor Information
>3tht Chain C (length=295) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TLLRHEGIETVSYATQSLVVANGGLGNGVSRNQLLPVLEKCGLVDALLMP
PNKPYSFARYRTTEESKRAYVTLNGKEVVDDLGQKITLYLNFVEKVQWKE
LRPQALPPGLMVVEEIISSEEEKMLLESVDWRRVKHFGYGLPDICESFLE
KWLRKGYIKHKPDQMTINQYEPGQGIPAHIDTHSAFEDEIVSLSLGSEIV
MDFKHPDGIAVPVMLPRRSLLVMTGESRYLWTHGITCRKFDTVQASEKSG
IITSDVGDLTLSKRGLRTSFTFRKVRQTPCNCSYPLVCDSQRKEN
Ligand information
Ligand IDAKG
InChIInChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)
InChIKeyKPGXRSRHYNQIFN-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04O=C(O)C(=O)CCC(=O)O
OpenEye OEToolkits 1.7.6C(CC(=O)O)C(=O)C(=O)O
CACTVS 3.385OC(=O)CCC(=O)C(O)=O
FormulaC5 H6 O5
Name2-OXOGLUTARIC ACID
ChEMBLCHEMBL1686
DrugBankDB08845
ZINCZINC000001532519
PDB chain3tht Chain C Residue 403 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3tht Crystal structure and RNA binding properties of the RNA recognition motif (RRM) and AlkB domains in human AlkB homolog 8 (ABH8), an enzyme catalyzing tRNA hypermodification.
Resolution3.01 Å
Binding residue
(original residue number in PDB)		N227 Y229 I235 H238 R328 S330 T332
Binding residue
(residue number reindexed from 1)		N168 Y170 I176 H179 R267 S269 T271
Annotation score1
Enzymatic activity
Enzyme Commision number 2.1.1.229: tRNA (carboxymethyluridine(34)-5-O)-methyltransferase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
Biological Process
GO:0070988 demethylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3tht, PDBe:3tht, PDBj:3tht
PDBsum3tht
PubMed22065580
UniProtQ96BT7|ALKB8_HUMAN Alkylated DNA repair protein alkB homolog 8 (Gene Name=ALKBH8)

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