Structure of PDB 3rae Chain C Binding Site BS03

Receptor Information
>3rae Chain C (length=208) Species: 1313 (Streptococcus pneumoniae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GKLTPAQSKNPAKNELYLVEGDSAGGSAKQGRDRKFQAILPLRGKVINTA
KAKMADILKNEEINTMIYTIGAGVGADFSIEDANYDKIIIMTDADTDGAH
IQTLLLTFFYRYMRPLVEAGHVYIALPPLYKYAWTDGELEELRKLQRYKG
LGEMNADQLWETTMNPETRTLIRVTIEDLARAERRVNVLMGDKVEPRRKW
IEDNVKFT
Ligand information
Receptor-Ligand Complex Structure
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PDB3rae Structure of a quinolone-stabilized cleavage complex of topoisomerase IV from Klebsiella pneumoniae and comparison with a related Streptococcus pneumoniae complex.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		D435 S436
Binding residue
(residue number reindexed from 1)		D22 S23
Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006265 DNA topological change

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Molecular Function
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Biological Process
External links
PDB RCSB:3rae, PDBe:3rae, PDBj:3rae
PDBsum3rae
PubMed27050128
UniProtQ59961|PARE_STRPN DNA topoisomerase 4 subunit B (Gene Name=parE)

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