Structure of PDB 3ob8 Chain C Binding Site BS03

Receptor Information
>3ob8 Chain C (length=1024) Species: 28985 (Kluyveromyces lactis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SCLIPENLRNPKKVHENRLPTRAYYYDQDIFESLNGPWAFALFDAPLDAP
DAKNLDWETAKKWSTISVPSHWELQEDWKYGKPIYTNVQYPIPIDIPNPP
TVNPTGVYARTFELDSKSIESFEHRLRFEGVDNCYELYVNGQYVGFNKGS
RNGAEFDIQKYVSEGENLVVVKVFKWSDSTYIEDQDQWWLSGIYRDVSLL
KLPKKAHIEDVRVTTTFVDSQYQDAELSVKVDVQGSSYDHINFTLYEPED
GSKVYDASSLLNEENGNTTFSTKEFISFSTKKNEETAFKINVKAPEHWTA
ENPTLYKYQLDLIGSDGSVIQSIKHHVGFRQVELKDGNITVNGKDILFRG
VNRHDHHPRFGRAVPLDFVVRDLILMKKFNINAVRNSHYPNHPKVYDLFD
KLGFWVIDEADLETHGVQEPFNRHTNLEAEYPDTKNKLYDVNAHYLSDNP
EYEVAYLDRASQLVLRDVNHPSIIIWSLGNEACYGRNHKAMYKLIKQLDP
TRLVHYEGDLNALSADIFSFMYPTFEIMERWRKNHTDENGKFEKPLILCE
YGHAMGNGPGSLKEYQELFYKEKFYQGGFIWEWANHGIEFEDVSTADGKL
HKAYAYGGDFKEEVHDGVFIMDGLCNSEHNPTPGLVEYKKVIEPVHIKIA
HGSVTITNKHDFITTDHLLFIDKDTGKTIDVPSLKPEESVTIPSDTTYVV
AVLKDDAGVLKAGHEIAWGQAELPLKVPDFVTETAEKAAKINDGKRYVSV
ESSGLHFILDKLLGKIESLKVKGKEISSKFEGSSITFWRPPTNNDEPRDF
KNWKKYNIDLMKQNIHGVSVEKGSNGSLAVVTVNSRISPVVFYYGFETVQ
KYTIFANKINLNTSMKLTGEYQPPDFPRVGYEFWLGDSYESFEWLGRGPG
ESYPDKKESQRFGLYDSKDVEEFVYDYPQENGNHTDTHFLNIKFEGAGKL
SIFQKEKPFNFKISDEYGVDEAAHACDVKRYGRHYLRLDHAIHGVGSEAC
GPAVLDQYRLKAQDFNFEFDLAFE
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain3ob8 Chain C Residue 3005 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3ob8 Structural basis of specificity in tetrameric Kluyveromyces lactis beta-galactosidase.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		D593 H975 D978
Binding residue
(residue number reindexed from 1)		D592 H974 D977
Annotation score4
Enzymatic activity
Catalytic site (original residue number in PDB) D187 H355 H389 E414 H416 E482 Y523 E551 H616 F620 D623
Catalytic site (residue number reindexed from 1) D186 H354 H388 E413 H415 E481 Y522 E550 H615 F619 D622
Enzyme Commision number 3.2.1.23: beta-galactosidase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004565 beta-galactosidase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0030246 carbohydrate binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0005990 lactose catabolic process
GO:0009056 catabolic process
Cellular Component
GO:0009341 beta-galactosidase complex

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:3ob8, PDBe:3ob8, PDBj:3ob8
PDBsum3ob8
PubMed22193516
UniProtP00723|BGAL_KLULA Beta-galactosidase (Gene Name=LAC4)

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