Structure of PDB 3ksa Chain C Binding Site BS03

Receptor Information

>3ksa Chain C (length=220) Species: 1313 (Streptococcus pneumoniae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

KLTPAQSKNPAKNELYLVEGDSAGGSAKQGRDRKFQAILPLRGKVINTAK
AKMADILKNEEINTMIYTIGAGVDFSIEANYDKIIIMTDADTDGAHIQTL
LLTFFYRYMRPLVEAGHVYIALPPLYKMSKKKEEVAYAWTDGELEELRKQ
FGKGATLQRYKGLGEMNADQLWETTMNPETRTLIRVTIEDLARAERRVNV
LMGDKVEPRRKWIEDNVKFT

Ligand information

>3ksa Chain H (length=11) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

gactatgcacg

Receptor-Ligand Complex Structure

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Structure summary

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PDB	3ksa Structural Basis of Gate-DNA Breakage and Resealing by Type II Topoisomerases
Resolution	3.3 Å
Binding residue (original residue number in PDB)	E433 D435 S436 G457
Binding residue (residue number reindexed from 1)	E19 D21 S22 G43

Enzymatic activity

Enzyme Commision number

5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0003918	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524	ATP binding

	Biological Process
GO:0006265	DNA topological change

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Molecular Function

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Biological Process

External links

PDB	RCSB:3ksa, PDBe:3ksa, PDBj:3ksa
PDBsum	3ksa
PubMed	20596531
UniProt	Q59961\|PARE_STRPN DNA topoisomerase 4 subunit B (Gene Name=parE)

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