Structure of PDB 2y9x Chain C Binding Site BS03

Receptor Information

>2y9x Chain C (length=391) Species: 5341 (Agaricus bisporus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

SDKKSLMPLVGIPGEIKNRLNILDFVKNDKFFTLYVRALQVLQARDQSDY
SSFFQLGGIHGLPYTEWAKAQPQLHLYKANYCTHGTVLFPTWHRAYESTW
EQTLWEAAGTVAQRFTTSDQAEWIQAAKDLRQPFWDWGYWPNDPDFIGLP
DQVIRDKQVEITDYNGTKIEVENPILHYKFHPIEPTFEGDFAQWQTTMRY
PDVQKQENIEGMIAGIKAAAPGFREWTFNMLTKNYTWELFSNHGAVVGAH
ANSLEMVHNTVHFLIGRDPTLDPLVPGHMGSVPHAAFDPIFWMHHCNVDR
LLALWQTMNYDVYVSEGMNREATMGLIPGQVLTEDSPLEPFYTKNQDPWQ
SDDLEDWETLGFSYPDFDPVKGKSKEEKSVYINDWVHKHYG

Ligand information

Ligand ID

0TR

InChI

InChI=1S/C7H6O2/c8-6-4-2-1-3-5-7(6)9/h1-5H,(H,8,9)

InChIKey

MDYOLVRUBBJPFM-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.352	OC1=CC=CC=CC1=O
OpenEye OEToolkits 1.6.1	C1=CC=C(C(=O)C=C1)O

Formula

C7 H6 O2

Name

2-HYDROXYCYCLOHEPTA-2,4,6-TRIEN-1-ONE;
TROPOLONE

PDB chain

2y9x Chain C Residue 410 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	2y9x Crystal Structure of Agaricus Bisporus Mushroom Tyrosinase: Identity of the Tetramer Subunits and Interaction with Tropolone.
Resolution	2.78 Å
Binding residue (original residue number in PDB)	H61 H85 N260 H263 V283
Binding residue (residue number reindexed from 1)	H60 H84 N259 H262 V282
Annotation score	1

Enzymatic activity

Enzyme Commision number

1.14.18.1: tyrosinase.

Gene Ontology

	Molecular Function
GO:0016491	oxidoreductase activity

View graph for
Molecular Function

External links

PDB	RCSB:2y9x, PDBe:2y9x, PDBj:2y9x
PDBsum	2y9x
PubMed	21598903
UniProt	C7FF04\|PPO3_AGABI Polyphenol oxidase 3 (Gene Name=PPO3)

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