Structure of PDB 2i55 Chain C Binding Site BS03

Receptor Information

>2i55 Chain C (length=242) Species: 5665 (Leishmania mexicana)

KAILLFDVDGTLTPPRNPETHDMKEALLKARAAGFKLGVVGGSDFAKQKE
QLGESILEDFDYVFSENGLLAYKDGKEFHRNSLLRALGNEKVVAFVKKCL
HLIADLDIPVQRGTFVEFRNGMFNVSPIGRNCSQQERDEFENLDKERHIR
EKLIRELKEAFPDYQLAYSVGGQISFDVFPKGWDKTYCLQFVENDFETIH
FFGDKTSEGGNDYEIFTDSRTIGHSVKTYKDTIAILEALLED

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 2i55 Chain C Residue 2005

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2i55 Structure of Leishmania mexicana phosphomannomutase highlights similarities with human isoforms
• Resolution: 2.9 Å
• Binding residue (original residue number in PDB): F219 T220 D221 T224
• Binding residue (residue number reindexed from 1): F216 T217 D218 T221
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 5.4.2.8: phosphomannomutase.

Gene Ontology

Molecular Function

• GO:0004615 phosphomannomutase activity
• GO:0016853 isomerase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006013 mannose metabolic process
• GO:0006487 protein N-linked glycosylation
• GO:0009298 GDP-mannose biosynthetic process

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:2i55, PDBe:2i55, PDBj:2i55
• PDBsum: 2i55
• PubMed: 16963079
• UniProt: Q95ZD7