Structure of PDB 2ch2 Chain C Binding Site BS03

Receptor Information
>2ch2 Chain C (length=387) Species: 7165 (Anopheles gambiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FTPPPASLRNPLIIPEKIMMGPGPSNCSKRVLTAMTNTVLSNFHAELFRT
MDEVKDGLRYIFQTENRATMCVSGSAHAGMEAMLSNLLEEGDRVLIAVNG
IWAERAVEMSERYGADVRTIEGPPDRPFSLETLARAIELHQPKCLFLTHG
DSSSGLLQPLEGVGQICHQHDCLLIVDAVASLCGVPFYMDKWEIDAVYTG
AQKVLGAPPGITPISISPKALDVIRNRRTKSKVFYWDLLLLGNYWGCYDE
PKRYHHTVASNLIFALREALAQIAEEGLENQIKRRIECAQILYEGLGKMG
LDIFVKDPRHRLPTVTGIMIPKGVDWWKVSQYAMNNFSLEVQGGLGPTFG
KAWRVGIMGECSTVQKIQFYLYGFKESLKATHPDYIF
Ligand information
Ligand IDKY1
InChIInChI=1S/C10H11NO3/c11-8-4-2-1-3-7(8)9(12)5-6-10(13)14/h1-4H,5-6,11H2,(H,13,14)
InChIKeyBIASMBPERGWEBX-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0c1ccc(c(c1)C(=O)CCC(=O)O)N
CACTVS 3.341Nc1ccccc1C(=O)CCC(O)=O
ACDLabs 10.04O=C(c1ccccc1N)CCC(=O)O
FormulaC10 H11 N O3
Name4-(2-AMINOPHENYL)-4-OXOBUTANOIC ACID
ChEMBLCHEMBL1233898
DrugBankDB08060
ZINCZINC000013356580
PDB chain2ch2 Chain C Residue 1390 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB2ch2 Crystal Structure of the Anopheles Gambiae 3-Hydroxykynurenine Transaminase
Resolution2.7 Å
Binding residue
(original residue number in PDB)		N44 F45 Y256
Binding residue
(residue number reindexed from 1)		N42 F43 Y254
Annotation score2
Enzymatic activity
Enzyme Commision number 2.6.1.44: alanine--glyoxylate transaminase.
2.6.1.63: kynurenine--glyoxylate transaminase.
Gene Ontology
Molecular Function
GO:0004760 L-serine-pyruvate transaminase activity
GO:0008453 alanine-glyoxylate transaminase activity
GO:0008483 transaminase activity
GO:0016740 transferase activity
GO:0030170 pyridoxal phosphate binding
GO:0047315 kynurenine-glyoxylate transaminase activity
Biological Process
GO:0009436 glyoxylate catabolic process
GO:0019265 glycine biosynthetic process, by transamination of glyoxylate
GO:0097053 L-kynurenine catabolic process
Cellular Component
GO:0005777 peroxisome

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:2ch2, PDBe:2ch2, PDBj:2ch2
PDBsum2ch2
PubMed16585514
UniProtQ7PRG3|HKT_ANOGA 3-hydroxykynurenine transaminase (Gene Name=HKT)

[Back to BioLiP]