Structure of PDB 1l0l Chain C Binding Site BS03

Receptor Information
>1l0l Chain C (length=377) Species: 9913 (Bos taurus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NIRKSHPLMKIVNNAFIDLPAPSNISSWWNFGSLLGICLILQILTGLFLA
MHYTSDTTTAFSSVTHICRDVNYGWIIRYMHANGASMFFICLYMHVGRGL
YYGSYTFLETWNIGVILLLTVMATAFMGYVLPWGQMSFWGATVITNLLSA
IPYIGTNLVEWIWGGFSVDKATLTRFFAFHFILPFIIMAIAMVHLLFLHE
TGSNNPTGISSDVDKIPFHPYYTIKDILGALLLILALMLLVLFAPDLLGD
PDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALAFSILILA
LIPLLHTSKQRSMMFRPLSQCLFWALVADLLTLTWIGGQPVEHPYITIGQ
LASVLYFLLILVLMPTAGTIENKLLKW
Ligand information
Ligand IDFMX
InChIInChI=1S/C22H18N2O4/c1-22(16-12-14-19(15-13-16)27-18-10-6-3-7-11-18)20(25)24(21(26)28-22)23-17-8-4-2-5-9-17/h2-15,23H,1H3/t22-/m0/s1
InChIKeyPCCSBWNGDMYFCW-QFIPXVFZSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C[C@@]1(C(=O)N(C(=O)O1)Nc2ccccc2)c3ccc(cc3)Oc4ccccc4
CACTVS 3.341C[C]1(OC(=O)N(Nc2ccccc2)C1=O)c3ccc(Oc4ccccc4)cc3
CACTVS 3.341C[C@]1(OC(=O)N(Nc2ccccc2)C1=O)c3ccc(Oc4ccccc4)cc3
OpenEye OEToolkits 1.5.0CC1(C(=O)N(C(=O)O1)Nc2ccccc2)c3ccc(cc3)Oc4ccccc4
ACDLabs 10.04O=C2OC(C(=O)N2Nc1ccccc1)(c4ccc(Oc3ccccc3)cc4)C
FormulaC22 H18 N2 O4
NameFAMOXADONE;
5-METHYL-5-(4-PHENOXYPHENYL)-3-(PHENYLAMINO)-2,4-OXAZOLIDINEDIONE
ChEMBLCHEMBL10118
DrugBankDB07778
ZINCZINC000006491064
PDB chain1l0l Chain C Residue 611 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1l0l The Crystal Structure of Mitochondrial Cytochrome bc1 in Complex with Famoxadone: The Role of Aromatic-Aromatic Interaction in Inhibition
Resolution2.35 Å
Binding residue
(original residue number in PDB)		M124 F128 Y131 G142 V145 I146 P270 E271 Y273 F274
Binding residue
(residue number reindexed from 1)		M122 F126 Y129 G140 V143 I144 P268 E269 Y271 F272
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) H201 S205 K227 D228 E271
Catalytic site (residue number reindexed from 1) H199 S203 K225 D226 E269
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0008121 ubiquinol-cytochrome-c reductase activity
GO:0009055 electron transfer activity
GO:0016491 oxidoreductase activity
GO:0020037 heme binding
GO:0046872 metal ion binding
GO:0048039 ubiquinone binding
Biological Process
GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c
GO:0022904 respiratory electron transport chain
GO:1902600 proton transmembrane transport
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016020 membrane
GO:0031966 mitochondrial membrane
GO:0045275 respiratory chain complex III

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1l0l, PDBe:1l0l, PDBj:1l0l
PDBsum1l0l
PubMed12269811
UniProtP00157|CYB_BOVIN Cytochrome b (Gene Name=MT-CYB)

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