Structure of PDB 7o80 Chain By Binding Site BS03

Receptor Information
>7o80 Chain By (length=416) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SAADRNVEIWKIKKLIKSLEAARGNGTSMISLIIPPKDQISRVAKMLADE
FGTASNIKSRVNRLSVLGAITSVQQRLKLYNKVPPNGLVVYCGTIVTEEG
KEKKVNIDFEPFKPINTSLYLCDNKFHTEALTALLSDDSKFGFIVIDGSG
ALFGTLQGNTREVLHKFTVDLPKKHGRAAQSALRFARLRMEKRHNYVRKV
AETAVQLFISGDKVNVAGLVLAGSADFKTELSQSDMFDQRLQSKVLKLVD
ISYGGENGFNQAIELSTEVLSNVKFIQEKKLIGRYFDEISQDTGKYCFGV
EDTLKALEMGAVEILIVYENLDIMRYVLHCQGTEEEKILYLTPEQEKDKS
HFTDKETGQEHELIESMPLLEWFANNYKKFGATLEIVTDKSQEGSQFVKG
FGGIGGILRYRVDFQG
Ligand information
>7o80 Chain AT (length=86) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
accgggauggccgagugguuaaggcguuggacuuaagauccaaugggcua
gugcccgcguggguucgaaccccacucucgguacca
<<<<<<<..<<<..........>>><<<<<<.......>>>>>>.<<<..
..>>>...<<<<<.......>>>>>>>>>>>>....
Receptor-Ligand Complex Structure
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PDB7o80 Structural basis of ribosomal frameshifting during translation of the SARS-CoV-2 RNA genome.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		K50 H180 G181
Binding residue
(residue number reindexed from 1)		K45 H175 G176
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003747 translation release factor activity
GO:0004045 aminoacyl-tRNA hydrolase activity
GO:0008079 translation termination factor activity
GO:0016149 translation release factor activity, codon specific
GO:1990825 sequence-specific mRNA binding
Biological Process
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0002184 cytoplasmic translational termination
GO:0006412 translation
GO:0006415 translational termination
GO:0006449 regulation of translational termination
GO:0006479 protein methylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0018444 translation release factor complex
GO:0022626 cytosolic ribosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7o80, PDBe:7o80, PDBj:7o80
PDBsum7o80
PubMed34029205
UniProtP62497|ERF1_RABIT Eukaryotic peptide chain release factor subunit 1 (Gene Name=ETF1)

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