Structure of PDB 8ova Chain Bx Binding Site BS03

Receptor Information
>8ova Chain Bx (length=235) Species: 5702 (Trypanosoma brucei brucei) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
APSPFVARPKDFGIGRDVPYARDLSRFMRWPTFVTMQRKKRVLQRRLKVP
PALNQFTKVLDRSSRNELLKLVKKYAPETRKARRDRLTKVAEEKKKNPTK
APLCVVSGLQEVTRTIEKKTARLVLIANNVDPIELVLWMPTLCRANKIPY
AIVKDKARLGDAIGRKTATCVAFTDVNAEDQAALKNLTRSVNARFLARSD
VIRRQWGGLQLSLRSRAELRKKRARTAGNDAAAKA
Ligand information
>8ova Chain BC (length=160) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
aacgugucgcgauggaugacuuggcuuccuauuucguugaagaacgcagc
aaagugcgauaagugguaucaauugcagaaauugcccaaucuuugaacgc
aaacggcgcaugggagaagcucgagccauccccgugcaugccacauuucu
cagugucgaa
.........................................<<<<<<<<<
....>>>>.....(<<<<......>>......>>>>.)...>>>....<<
.....>><<<<<<<....<<<..>>>....>>>>>>>.............
..........
Receptor-Ligand Complex Structure
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PDB8ova A single pseudouridine on rRNA regulates ribosome structure and function in the mammalian parasite Trypanosoma brucei.
Resolution2.47 Å
Binding residue
(original residue number in PDB)		R61 Q72 R73 R100 K194 D195 R198
Binding residue
(residue number reindexed from 1)		R26 Q37 R38 R65 K154 D155 R158
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0000470 maturation of LSU-rRNA
GO:0006412 translation
Cellular Component
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8ova, PDBe:8ova, PDBj:8ova
PDBsum8ova
PubMed37985661
UniProtQ57VM1

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