Structure of PDB 8ove Chain Bf Binding Site BS03

Receptor Information
>8ove Chain Bf (length=400) Species: 5702 (Trypanosoma brucei brucei) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SHCKFEHPRHGHLGFLPRKRSRQIRGRARSFPKDDPSQKPHLTSFMVYKA
GMTHIVRDVDRPGSKVNKKEVVEPVTILEAPPMVVVGIVGYRQTPVGHKT
IGTVWAHHTSVEFRRRFYKNWKQSAQLAFTKRKQFARTTEGRLAEARTLK
AFEKKADIIRVVAHTQLRKLRNNRVGVKKAHVSEIQINGGTIAQKIELAK
SLLEKEVRIDSVFQQSEACDVCAVTKGHGFTGVVKRWGVACLPRKTHRGL
RKVACIGAWHPSRVMYTVARAGQHGYHHRTHLNKKIYQLGRAVSMEPNQA
TTAYDLTAKTITPMGGFVGYGTVRNDYVMLKGSVAGPRRRVITLRRPMAP
QTSRKLTEKITLKFIDTSSKIGHGRFQTKKEKSQWYGPLKKDRIRREERL
Ligand information
>8ove Chain BG (length=183) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gugagauugugaagggaucucgcaggcaucgugagggaaguaugggguag
uacgagaggaacucccaugccgugccucugguuucuggaguuugucgaag
ggcaagugcuccgacgcuaucgcacggugguucucggcugaacgccucua
agccagaaaccagucccaagaccgggugcccgu
<<<<<<<.........>>>>>>>.<<<<<<....<<<<.<<<<<<<<...
............>>>>>>>><<<<<...<<<<....<<<<<<<<<.....
.>>>>..>>>>>...>>>>..>>>>>.<<<<..<.<<<<...........
>>>>.>..>>>>.>>>>.......>>>>>>...
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8ove A single pseudouridine on rRNA regulates ribosome structure and function in the mammalian parasite Trypanosoma brucei.
Resolution2.6 Å
Binding residue
(original residue number in PDB)		G12 H13 L14 G15 F16 P18 R26 R30 S31 K50 M53 T54 H55 S65 P75 Y92 H99 T101 W106 F118 L128 F130 K132 R133 R161 E185 T226 K227 H279 R280 H282 L283 S334 V335 R355 G373 H374
Binding residue
(residue number reindexed from 1)		G11 H12 L13 G14 F15 P17 R25 R29 S30 K49 M52 T53 H54 S64 P74 Y91 H98 T100 W105 F117 L127 F129 K131 R132 R160 E184 T225 K226 H278 R279 H281 L282 S333 V334 R354 G372 H373
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005762 mitochondrial large ribosomal subunit
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8ove, PDBe:8ove, PDBj:8ove
PDBsum8ove
PubMed37985661
UniProtQ581Q1

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