Structure of PDB 8ova Chain Bf Binding Site BS03

Receptor Information
>8ova Chain Bf (length=396) Species: 5702 (Trypanosoma brucei brucei) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SHCKFEHPRHGHLGFLPRKRSRQIRGRARSFPKDDPSQKPHLTSFMVYKA
GMTHIVRDVDRPGSKVNKKEVVEPVTILEAPPMVVVGIVGYRQTPVGHKT
IGTVWAHHTSVEFRRRFYKNWKQSAQLAFTKRKQFARTTEGRLAEARTLK
AFEKKADIIRVVAHTQLRKLRNNRVGVKKAHVSEIQINGGTIAQKIELAK
SLLEKEVRIDSVFQQSEACDVCAVTKGHGFTGVVKRWGVACLPRKTHRGL
RKVACIGAWHPSRVMYTVARAGQHGYHHRTHLNKKIYQLGRAVSMEPNQA
TTAYDLTAKTITPMGGFVGYGTVRNDYVMLKGSVAGPRRRVITLRRPMAP
QTSRKLTEKITLKFIDTSSKIGHGRFQTKKEKSQWYGPLKKDRIRR
Ligand information
>8ova Chain BH (length=119) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ugucccucuccaaacgagaguacaugcaugggcuggcaugagcggcacgc
ucggggcucgaggggcaccgucccgaggcgcugaaccuugaugcuuggaa
uuucaugcucagggacuuu
.<<<<<.<<<.......>>>.....<<<<<<<<.<<.....<<<....<.
<....>.>....<<<......>>>....>>>....>>.....>>>.....
...>>>>>...>>>>>...
Receptor-Ligand Complex Structure
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PDB8ova A single pseudouridine on rRNA regulates ribosome structure and function in the mammalian parasite Trypanosoma brucei.
Resolution2.47 Å
Binding residue
(original residue number in PDB)		R21 R116 R117 K120 N121 K123 Q124 R172 N174 R175 G177 V178 K179 K180 G228 G230 F231 Y277 M315 G316 G320 G322 R325 R340 R341 S370 I372 K380 K383 Y387 K391 R394 R396
Binding residue
(residue number reindexed from 1)		R20 R115 R116 K119 N120 K122 Q123 R171 N173 R174 G176 V177 K178 K179 G227 G229 F230 Y276 M314 G315 G319 G321 R324 R339 R340 S369 I371 K379 K382 Y386 K390 R393 R395
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005762 mitochondrial large ribosomal subunit
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8ova, PDBe:8ova, PDBj:8ova
PDBsum8ova
PubMed37985661
UniProtQ581Q1

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