Structure of PDB 8ove Chain Be Binding Site BS03

Receptor Information
>8ove Chain Be (length=254) Species: 5702 (Trypanosoma brucei brucei) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GKTVLTCRKGNGSVYQVHGHKRLGPAKLRILDYAERHGFMRGVVKAIEHE
PGRGAPLARVEFRHPYKYRRVKELMVAPEGMFTGQSMLCGVKAPLAIGNV
LPLGQITEGCIVCNVEAKVGDRGTLARASGDYCIIISHNTETGRTRLKLP
SGQKKTVPSSCRAMIGIVAGGGRIEKPVLKAGNSFYRFRGKRNCWPKVRG
VARNPVEHPHGGGNHQHIGHPSTVSRHAPPGQKVGLIAARRTGRIRGSRA
VRGA
Ligand information
>8ove Chain BE (length=166) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
guggaaaugcgcuugccaggugacccauccauccucccacggugagcuuu
cuuuucaccauaauccaccuugggccucucgacgcguuacucggagcggg
ggcucaagauugaaaaaugcagcacugucugugaguucggcgcauuaaag
caaaaaccuggggugu
<<<....>>>..<..<<<<<<.......<<...<<<.<<.<<<<<<....
...>>>>>><...<<.<.<<<<<<<<<<<...<<.......>>....>>>
>>>>>>>>.>.>>....><<<<..>>>>.>>.>>>...>>..........
.....>>>>>>.>...
Receptor-Ligand Complex Structure
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PDB8ove A single pseudouridine on rRNA regulates ribosome structure and function in the mammalian parasite Trypanosoma brucei.
Resolution2.6 Å
Binding residue
(original residue number in PDB)		K22 H50 Y69 R174 K177 Y187
Binding residue
(residue number reindexed from 1)		K21 H49 Y68 R173 K176 Y186
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
Cellular Component
GO:0005730 nucleolus
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:0022626 cytosolic ribosome
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8ove, PDBe:8ove, PDBj:8ove
PDBsum8ove
PubMed37985661
UniProtQ57W56

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