Structure of PDB 7am2 Chain BW Binding Site BS03

Receptor Information
>7am2 Chain BW (length=447) Species: 5689 (Leishmania tarentolae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SPARTAQSPLLAKPVKTKVVDNFADMLVTPALQEALADMGVSTPSPIQQT
AIEAVLQRKNTVIAAPHGEGKTLAYLLPLYQNMEKDRDVYKIPLRERRPR
MILLAPTKELVEQLQTVCARLDAATGLTSVCFTSRKRSKYHLSRMLKNTM
ADVLVMDPKLILRLLRTRRLFIEDLRYFAVDEADAMMSSLHDHDAVQLLM
KVQKRNQFKYLWPVQTQYVFVTAYMTRKLEYIVGRKISDPVTCMFRQLMH
RPQARLRHRFYAIRREPEKFTVLMHLLRKNGHVPLPFAEGRRTIIFFRNI
DATTAVFHQLRSAGFAVSLLHASLPYKVRKEMYADFASGRTNILCATDVA
ARGLDLHVDMVINFDVPTNALAYLSRSGRTARMGREGQVLNLYNKHQGVI
VSAIKAFLKDNLPMEGLTNRKADMMQPRYAEWRTHKINALARSYVSL
Ligand information
Ligand IDATP
InChIInChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
InChIKeyZKHQWZAMYRWXGA-KQYNXXCUSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O)N
CACTVS 3.341Nc1ncnc2n(cnc12)[CH]3O[CH](CO[P](O)(=O)O[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]3O
ACDLabs 10.04O=P(O)(O)OP(=O)(O)OP(=O)(O)OCC3OC(n2cnc1c(ncnc12)N)C(O)C3O
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@@](=O)(O)O[P@](=O)(O)OP(=O)(O)O)O)O)N
CACTVS 3.341Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO[P@](O)(=O)O[P@@](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]3O
FormulaC10 H16 N5 O13 P3
NameADENOSINE-5'-TRIPHOSPHATE
ChEMBLCHEMBL14249
DrugBankDB00171
ZINCZINC000004261765
PDB chain7am2 Chain BW Residue 801 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7am2 Structure of the mature kinetoplastids mitoribosome and insights into its large subunit biogenesis.
Resolution3.4 Å
Binding residue
(original residue number in PDB)		V133 T135 Q140 H159 G160 G162 K163 T164 D571 M599
Binding residue
(residue number reindexed from 1)		V41 T43 Q48 H67 G68 G70 K71 T72 D355 M383
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003724 RNA helicase activity
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0016787 hydrolase activity
Biological Process
GO:1902775 mitochondrial large ribosomal subunit assembly
Cellular Component
GO:0005739 mitochondrion

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7am2, PDBe:7am2, PDBj:7am2
PDBsum7am2
PubMed33168716
UniProtQ4QHU1

[Back to BioLiP]