Structure of PDB 8ova Chain BT Binding Site BS03

Receptor Information
>8ova Chain BT (length=196) Species: 5702 (Trypanosoma brucei brucei) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SLKLQARLAADILRCGRGRVWLDPNEAVEIRNANSRKSVRKLIKDGLVMR
KPVKVHSRSRWRQMKLAKSMGRHEGTGRREGTREARMPSKDLWMRRLRIL
RRLLRKYREEKKIDRHIYRELYMKAKGNVFRNKRNLMEHIHKVKNEKKKA
RQLAEQLAAKRLKDEQNRRKARKQELKKREKERERARRDDAAAAAA
Ligand information
>8ova Chain BB (length=1119) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cccaacugcagaccguacucaucaccgcaucagguccccaagcaucgaau
gcucugguacauagagaaagguacacucagggaagucggcaaaauagaug
cguaaguucgcaagaagcauuggcucugagggcaaaaauugccaacucag
aacugcuuacggcggggaauccaacuguauaauuaaaacauagguuugug
augcauccaagugguguaugucgcaaacugauuucugcccagugcucugu
gucaacgugacgagauucaccgacgcgcggguaaacggcgggaguaacua
ugacucucuuaagguagccaaaugccucgucuuccaauuagagacgcgca
ugaauggauuaaugagauucccucugucccgaguuacuaucuagcgaaac
gacagucaagggaacggacuugaagggcuaagcggggaaagaagacccug
uugaguuugacuccagucuggcucugugcggcgacuuacguugcuucacu
uaucgaaugaagagaccaaugguuguuuugcgcagucuucgggcugugcg
ccgucuaggcugacgcgugcggaacuacugcgccaaacggggugguucuc
cggagucuuguuucgagacaucugccagauggggaguuuggcuggggcgg
cauaucuguuacacgacaacgcagguguccuaaggcgagcucagugggaa
cagaaaucucacguggaacacaagcguaaaugcuugcuugauuaacgauu
uccaguacgaaucgagacugcgaaagcaaggccagcgauccuuugcgaag
aacaggaaauaugaacaaaucauaccagaggugucagaauaauuaccaca
gggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuug
auccuucgaugucggcucuuccuaaccuagcgccgcagaagacgcuaagg
guuggauuguucacccacugacagggaacgugagcuggguuuagaccguc
gugagacagguugguuuuacccuacuuggcuggagauugcgaguaaaaga
uuauccgcgcaaagcggaggcaguccguuuuuuucugggucugccguugg
guggcaugugcuuggcgcu
........................<<......>>......<<<<<...>>
>>>........<<<<....<<<<.<<<<.<<.........<.....<<<<
<.....<..>......>>>>><<.<<<<<<<<<<<...>>>>>..>>>>>
>.>>..........<<<<<<<<<..<<<.........>>>..<<<<<<<.
...<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<<
<<....<<<<......>>>>....>>>>>>>>..>>>>><<<<<<.....
..>>>>>>........<...........<<<<<.......>>>>>.....
>.....>>....>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.......
.....<<<<<........>>>>>..<<<<<<<..<<<.<<......<<<<
.<<<<<<..<<<<<.<<<<<<<...<<<.<<<<<<....>>>>>>.>>>.
..<<<<<.....<<<<....<<<......<<<<<<<......>>>>>>>>
>>...<.<..<...>..>>....................<<<.<..>.>>
>...>>>>...>>>>>.......>>>>>>>..>>>>>...<<<.....>>
>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.
......>>>>>>.....<<......>>....>>>>>>>...<<...<<<<
<.......>>>>>..>>.<<<....>>>.>>.........<<<<<.....
.........<<<<.......>>>>.>>>>>..........>>>>..>>>>
>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>
.>.>.......<<<<<.<<<<<<..<<<<<<<.<......>.>>>>..>>
>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<
....>>>.>>>>....>>..>>>.>>>>>>>...................
....<<<<.....>>>>...<<<...........>>>..........<..
<.<.......>.>.>....
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8ova A single pseudouridine on rRNA regulates ribosome structure and function in the mammalian parasite Trypanosoma brucei.
Resolution2.47 Å
Binding residue
(original residue number in PDB)		G18 R19 R21 V55 K56 H58 R60 W63 R74 H75 G77 T78 G79 R80 R81 E82 G83 R85 R88 K114 N134 K135 H143
Binding residue
(residue number reindexed from 1)		G16 R17 R19 V53 K54 H56 R58 W61 R72 H73 G75 T76 G77 R78 R79 E80 G81 R83 R86 K112 N132 K133 H141
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
GO:0042254 ribosome biogenesis
Cellular Component
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8ova, PDBe:8ova, PDBj:8ova
PDBsum8ova
PubMed37985661
UniProtQ57ZI7

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