Structure of PDB 7ryk Chain BBB Binding Site BS03

Receptor Information

>7ryk Chain BBB (length=129) Species: 9031 (Gallus gallus)

KVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGS
TDYGILQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVS
DGNGMNAWVAWRNRCKGTDVQAWIRGCRL

Ligand information

• Ligand ID: NO3
• InChI: InChI=1S/NO3/c2-1(3)4/q-1
• InChIKey: NHNBFGGVMKEFGY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  CACTVS 3.341: [O-][N+]([O-])=O
  OpenEye OEToolkits 1.5.0: [N+](=O)([O-])[O-]
• Formula: N O3
• Name: NITRATE ION
• ChEMBL: CHEMBL186200
• DrugBank: DB14049
• PDB chain: 7ryk Chain BBB Residue 302

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7ryk Probing ion-binding at a protein interface: Modulation of protein properties by ionic liquids.
• Resolution: 1.76 Å
• Binding residue (original residue number in PDB): S24 L25 G26 Q121 I124
• Binding residue (residue number reindexed from 1): S24 L25 G26 Q121 I124
• Annotation score: 3

Enzymatic activity

• Enzyme Commision number: 3.2.1.17: lysozyme.

Gene Ontology

Molecular Function

• GO:0003796 lysozyme activity
• GO:0005515 protein binding
• GO:0016231 beta-N-acetylglucosaminidase activity
• GO:0016798 hydrolase activity, acting on glycosyl bonds
• GO:0042802 identical protein binding

Biological Process

• GO:0016998 cell wall macromolecule catabolic process
• GO:0031640 killing of cells of another organism
• GO:0042742 defense response to bacterium
• GO:0050829 defense response to Gram-negative bacterium
• GO:0050830 defense response to Gram-positive bacterium

Cellular Component

• GO:0005576 extracellular region
• GO:0005615 extracellular space
• GO:0005737 cytoplasm
• GO:0005783 endoplasmic reticulum

External links

• PDB: RCSB:7ryk, PDBe:7ryk, PDBj:7ryk
• PDBsum: 7ryk
• PubMed: 37480654
• UniProt: P00698|LYSC_CHICK Lysozyme C (Gene Name=LYZ)