Structure of PDB 6lqv Chain B1 Binding Site BS03

Receptor Information
>6lqv Chain B1 (length=793) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KSDFKFSNLLGTVYRQGNITFSDDGKQLLSPVGNRVSVFDLINNKSFTFE
YEHRKNIAAIDLNKQGTLLISIDEDGRAILVNFKARNVLHHFNFKEKCSA
VKFSPDGRLFALASGRFLQIWKTPDVNKDRQFAPFVRHRVHAGHFQDITS
LTWSQDSRFILTTSKDLSAKIWSVDSEEKNLAATTFNGHRDYVMGAFFSH
DQEKIYTVSKDGAVFVWEFTKRKYSWRITKKHFFYANQAKVKCVTFHPAT
RLLAVGFTSGEFRLYDLPDFTLIQQLSMGQNPVNTVSVNQTGEWLAFGSS
KLGQLLVYEWQSESYILKQQGHFDSTNSLAYSPDGSRVVTASEDGKIKVW
DITSGFCLATFEEHTSSVTAVQFAKRGQVMFSSSLDGTVRAWDLIRYRNF
RTFTGTERIQFNCLAVDPSGEVVCAGSLDNFDIHVWSVQTGQLLDALSGH
EGPVSCLSFSQENSVLASASWDKTIRIWSIFGRSQQVEPIEVYSDVLALS
MRPDGKEVAVSTLKGQISIFNIEDAKQVGNIDCRKDIISGRFNQDRFTAK
NSERSKFFTTIHYSFDGMAIVAGGNNNSICLYDVPNEVLLKRFIVSRNMA
LNGTLEFLNSKMRPEVRVTSVQFSPTANAFAAASTEGLLIYSTNDTILFD
PFDLDVDVTPHSTVEALREKQFLNALVMAFRLNEEYLINKVYEAIPIKEI
PLVASNIPAIYLPRILKFIGDFAIESQHIEFNLIWIKALLSASGGYINEH
KYLFSTAMRSIQRFIVRVAKEVVNTTTDNKYTYRFLVSTDGSM
Ligand information
>6lqv Chain SA (length=950) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
aagauaguuaucugguugauccugccaguagucauaugcuugucucagcc
augcaugucuaaguauaagcaauuuauacagugaaacugcgaaggcucau
uaaaucaguuaucguuuauuugauaguuccaugguauaacugugguaauu
cuagagcuaauacaugcuaaucucgacccuuuggaagagauguauuuauu
agaucaaugucuucggacucuuugaugaaauaacuuuucgaaucgcaugg
ccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgau
gguaggauaguggccuaccaugguuucaacggguaacggggaauaagggu
ucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggc
agcaggccaaauuacccaauccuaauucagggagguagugacaauaaaua
acgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaa
uaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgg
uaauuccagcuccaauagcguauauuaaaguuguugcagcuggggggagu
auggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccagg
aguggagccugcggcucaacacggggaaacucaccagguccagacacaau
aaggauugacauucuugauuuugugggugguggugcauugaugcccuugu
ucugggccacgcgcgcuacacugacggagccagcgagucuagugaaacuc
cgucgugcuggcaacgaggaauuccuaguaagcgcaagucaucagcuugc
guugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgau
ugaauggcuuagugaggcgacaaacuuggucauuuagaggaacuaaaagu
............................<<<<.<<<<<<........<<<
.<<...<<....<<....<<..........>>...>>.>>.....<<<..
.....<<<..<<..<<....<<<..........<.....<<.<<......
.>>.>>......>.......<<<<............>>>>.....<<<<<
...<<<<..............>>>>...>>>>>.........<<<<...<
<.....>>..>>>>....>>>...>>>>..>>>.<<<....<<<....<<
<<<<<<.......>>>>>>>>>>>......>>>.....<<..........
.....>>..>>>.<<.<<<..........>>>.>>.<.<<....>>.>..
..>>>>>......<<<....<<<.....>>>..>>>..............
.<<<<<<<.<<<<<....>>>>>.>>>.>>>>......<<..<.......
....>..>>.........<<<<<<.......<<<....>>>.........
.........>>>>>>..>>>>>>>>>>.........<....>........
............<<.........>>.....<<<<<<<<<<<<..<<.<<<
<<<..<<<.<<<<.......................<<.<....<<<<<.
.......<.....>......>>>>>......<<<........>>>...>.
>>.......>>>>.>>>.....<<<<<<<..................>>>
>>>>................>>>>>>....<<<<<<<<.......>>>>>
>>>......>>...>>>>>>>............>>>>>..<<<<.<<...
..<<<<<<<.<<<..<....>..>>>.>>>>>>>....>>.>>>>.....
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6lqv Cryo-EM structure of 90 S small ribosomal subunit precursors in transition states.
Resolution4.8 Å
Binding residue
(original residue number in PDB)		K397 D415 R418 R420 F422 R423 R505
Binding residue
(residue number reindexed from 1)		K375 D393 R396 R398 F400 R401 R483
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003729 mRNA binding
GO:0005515 protein binding
Biological Process
GO:0000028 ribosomal small subunit assembly
GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000920 septum digestion after cytokinesis
GO:0006364 rRNA processing
GO:0030010 establishment of cell polarity
GO:0030490 maturation of SSU-rRNA
GO:0042254 ribosome biogenesis
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0030686 90S preribosome
GO:0032040 small-subunit processome
GO:0034388 Pwp2p-containing subcomplex of 90S preribosome
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6lqv, PDBe:6lqv, PDBj:6lqv
PDBsum6lqv
PubMed32943522
UniProtP25635|PWP2_YEAST Periodic tryptophan protein 2 (Gene Name=PWP2)

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