Structure of PDB 8z9r Chain B Binding Site BS03

Receptor Information
>8z9r Chain B (length=676) Species: 126796 (Thogoto virus (isolate SiAr 126)) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MNLFTPLSEINPTTTQELLYAYTGPAPVAYGTRTRAVLENIIRPYQYFYK
EPNVQRALDIKTGCKEPEDINVEGPSSGFHTASVLKLADNFFRKYRPAME
KLKYWILVKLPKLKYAELSKGRQTYSFIHKRNLPAPIALEETVEFLEQNL
RRKIGPTLLSYCQAIADVMELDETTYEGARTYTIKFSREELWDQMRTLNT
MWKHLERGRLNRRTIATPSMLIRGFVKIVEDAAKEILENVPTSGVPVGGE
EKLAKLASKQTFHTAVTGELSGDQEKFNECLDPDAMRLMWTVFLRKLGCP
DWIMELFNIPFMVFKSKLADMGEGLVYTKGKLTDRKPLGEMPSEFDDLVR
NVVGNSISCRLGMFMGMYNLTSTLLALISIEREELTGSHVESSDDFIHFF
NCKTHEEMFKQAETLRLTLKLVGINMSPSKCILISPAGIGEFNSKFHHRD
FVGNVATELPALVPNGTNPMTDLAMGLNVIKHSVNTGQMNLCTGALAMRI
FNHAYKYAYMALGVTRRTRFMEENAITPLLTNQGASPVHSFSTMHLDEVA
LRRHLGLLDEETLRRILNPNNPVTQKGDPSMFFRIENKMPQIMEDYSVPS
CFKYTLSRNRHKALLNKEERYQRVTSIINKLFPEVLIQEASAPGTVRESL
KRRLELVVERSDLDEERKKRILSRIF
Ligand information
Receptor-Ligand Complex Structure
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PDB8z9r Cryo-EM structures of Thogoto virus polymerase reveal unique RNA transcription and replication mechanisms among orthomyxoviruses
Resolution2.58 Å
Binding residue
(original residue number in PDB)		R122 Q123 N132 M229 I243 A244 R251 K262 P274 G394 M395 N397 T499 M503 N506 H510 K604
Binding residue
(residue number reindexed from 1)		R122 Q123 N132 M201 I215 A216 R223 K234 P246 G366 M367 N369 T471 M475 N478 H482 K576
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0001172 RNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:8z9r, PDBe:8z9r, PDBj:8z9r
PDBsum8z9r
PubMed38816392
UniProtO41353|RDRP_THOGV RNA-directed RNA polymerase catalytic subunit (Gene Name=Segment)

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