Structure of PDB 8z97 Chain B Binding Site BS03

Receptor Information
>8z97 Chain B (length=670) Species: 126796 (Thogoto virus (isolate SiAr 126)) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MNLFTPLSEINPTTTQELLYAYTGPAPVAYGTRTRAVLENIIRPYQYFYK
EPNVQRALDIKTGCKEPEDINVEGPSSGFHTASVLKLADNFFRKYRPAME
KLKYWILVKLPKLKYAELSKGRQTYSFIHKRNLPAPIALEETVEFLEQNL
RRKIGPTLLSYCQAIADVMELDETTYEGARTYTIKFSREELWDQMRTLNT
MWKHLERGRLNRRTIATPSMLIRGFVKIVEDAAKEILENVPTSGVPVGGE
EKLAKLASKQTFHTAVTGELSGDQEKFNECLDPDAMRLMWTVFLRKLGCP
DWIMELFNIPFMVFKSKLADMGEGLVYTKGKLTDRKPLGEMPSEFDDLVR
NVVGNSISCRLGMFMGMYNLTSTLLALISIEREELTGSHVESSDDFIHFF
NCKTHEEMFKQAETLRLTLKLVGINMSPSKCILISPAGIGEFNSKFHHRD
FVGNVATELPALVPNGTNPMTDLAMGLNVIKHSVNTGQMNLCTGALAMRI
FNHAYKYAYMALGVTRRTRFMEENAITPLLTNQGASPVHSFSTMHLDEVA
LRRHLGLLDEETLRRILNPNNPVTQKGDPSMFFRIENKMPQIMEDYSVPS
CFKYTLSRNRKEERYQRVTSIINKLFPEVLIQEASAPGTVRESLKRRLEL
VVERSDLDEERKKRILSRIF
Ligand information
Receptor-Ligand Complex Structure
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PDB8z97 Cryo-EM structures of Thogoto virus polymerase reveal unique RNA transcription and replication mechanisms among orthomyxoviruses
Resolution2.65 Å
Binding residue
(original residue number in PDB)		G121 R122 Q123 N132 I243 A244 T245 R251 K262 V273 P274 G277 G394 M503 N506 H510
Binding residue
(residue number reindexed from 1)		G121 R122 Q123 N132 I215 A216 T217 R223 K234 V245 P246 G249 G366 M475 N478 H482
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0001172 RNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:8z97, PDBe:8z97, PDBj:8z97
PDBsum8z97
PubMed38816392
UniProtO41353|RDRP_THOGV RNA-directed RNA polymerase catalytic subunit (Gene Name=Segment)

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