Structure of PDB 8v9q Chain B Binding Site BS03

Receptor Information
>8v9q Chain B (length=449) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GPGEMPVVIPKEKMKEMFKINQASEMIALNRSLPDVRLEGCKTKVYPDNL
PTTSVVIFHNESTLRTVHSVINRSPRHMIEEIVDASERDFLKRPSYVKKL
KVPVVIREQRSGLIRARLSRGQVTFLDAHCETAGWLEPLLARIKHDRRTV
CPIIDVISDDTFEYMAGSDMTYGFNWKLNFRWYPVPQREMDRRKGDRTLP
VRTPTMALFSIDRDYFQEIGTYDAGMDIWGGENLEISFRIWQCGGTLEIV
TCSHVGHVFRKATPYQIINKNNRRLAEVWMDEFKNFFYIISVTKVDYGDI
SSRLGLRRKLQCKPFSWYLENIYPDSQIPRHYFSLGEIRNVETNQCLDNM
AKENEKVGIFNCHGMGNQVFSYTANKEIRTDDLCLDVSKLNPVTMLKCHH
LKNQLWEDPVKLTLQHVNSNQCLDKAQVPSIRDCTGSRSQQWLLRNVTL
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain8v9q Chain B Residue 604 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8v9q An unusual dual sugar-binding lectin domain controls the substrate specificity of a mucin-type O-glycosyltransferase.
Resolution2.29 Å
Binding residue
(original residue number in PDB)		H211 H344 R347
Binding residue
(residue number reindexed from 1)		H129 H257 R260
Annotation score1
Enzymatic activity
Enzyme Commision number 2.4.1.41: polypeptide N-acetylgalactosaminyltransferase.
Gene Ontology
Molecular Function
GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity
GO:0016757 glycosyltransferase activity
GO:0030145 manganese ion binding
GO:0030246 carbohydrate binding
GO:0046872 metal ion binding
Biological Process
GO:0006486 protein glycosylation
GO:0006493 protein O-linked glycosylation
GO:0018242 protein O-linked glycosylation via serine
GO:0018243 protein O-linked glycosylation via threonine
Cellular Component
GO:0005576 extracellular region
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0032580 Golgi cisterna membrane
GO:0048471 perinuclear region of cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8v9q, PDBe:8v9q, PDBj:8v9q
PDBsum8v9q
PubMed38416819
UniProtO08912|GALT1_MOUSE Polypeptide N-acetylgalactosaminyltransferase 1 (Gene Name=Galnt1)

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