Structure of PDB 8p4a Chain B Binding Site BS03

Receptor Information
>8p4a Chain B (length=1116) Species: 9823 (Sus scrofa) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EITPDLWQEACWIVISSYFDEKGLVRQQLDSFDEFIQMSVQRIVEDAPPI
DLQPPRYLLKFEQIYLSKPTHWDGAPSPMMPNEARLRNLTYSAPLYVDIT
KTVQLQTQHQKTFIGKIPIMLRSTYCLLNGLTDRDLCELNECPLDPGGYF
IINGSEKVLIAQEKMATNTVYVFAKKDSKYAYTGECRSCLENSSRPTSTI
WVSMLARQRIVATLPYIKQEVPIIIVFRALGFVSDRDILEHIIYDFEDPE
MMEMVKPSLDEAFVIQEQNVALNFIGSRGAKPGVTKEKRIKYAKEVLQKE
MLPHVGVSDFCETKKAYFLGYMVHRLLLAALGRRELDDRDHYGNKRLDLA
GPLLAFLFRGMFKNLLKEVRIYAQKFIDRGKDFNLELAIKTRIISDGLKY
SLATGNWGDARAGVSQVLNRLTFASTLSHLRRLNSPIGRDGKLAKPRQLH
NTLWGMVCPAETPEGHAVGLVKNLALMAYISVGSQPSPILEFLEEWSMEN
LEEISPAAIADATKIFVNGCWVGIHKDPEQLMNTLRKLRRQMDIIVSEVS
MIRDIREREIRIYTDAGRICRPLLIVEKQKLLLKKRHIDQLKEREYNNYS
WQDLVASGVVEYIDTLEEETVMLAMTPDDLQEKEVAYCSTYTHCEIHPSM
ILGVCASIIPFPDHNQSPRNTYQSAMGKQAMGVYITNFHVRMDTLAHVLY
YPQKPLVTTRSMEYLRFRELPAGINSIVAIASYTGYNQEDSVIMNRSAVD
RGFFRSVFYRSYKEQESKKGFDQEEVFEKPTRETCQGMRHAIYDKLDDDG
LIAPGVRVSGDDVIIGKTVTLPENEDRRYTKRDCSTFLRTSETGIVDQVM
VTLNQEGYKFCKIRVRSVRIPQIGDKFASRHGQKGTCGIQYRQEDMPFTC
EGITPDIIINPHAIPSRMTIGHLIECLQGKVSANKGEIGDATPFNDAVNV
QKISNLLSDYGYHLRGNEVLYNGFTGRKITSQIFIGPTYYQRLKHMVDDK
IHSRARGPIQILNRQPMEGRSRDGGLRFGEMERDCQIAHGAAQFLRERLF
EASDPYQVHVCNLCGIMAIANTRTHTYECRGCRNKTQISLVRMPYACKLL
FQELMSMSIAPRMMSV
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8p4a Chain B Residue 2000 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8p4a Structural insights into human co-transcriptional capping.
Resolution3.6 Å
Binding residue
(original residue number in PDB)		C1119 C1137 C1140
Binding residue
(residue number reindexed from 1)		C1061 C1079 C1082
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0001055 RNA polymerase II activity
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0003968 RNA-dependent RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0032549 ribonucleoside binding
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0006351 DNA-templated transcription
GO:0006366 transcription by RNA polymerase II
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0000781 chromosome, telomeric region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005665 RNA polymerase II, core complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8p4a, PDBe:8p4a, PDBj:8p4a
PDBsum8p4a
PubMed37369200
UniProtI3LGP4

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