Structure of PDB 8jxe Chain B Binding Site BS03

Receptor Information

>8jxe Chain B (length=1468) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

QPFHCPSTQWQCPGYSTCINLSALCDGVFDCPNGTDESPLCNQDSCSHFN
GGCTHQCMQGPFGATCLCPLGYQLANDTKTCEDINECDIPGFCSQHCVNM
RGSFRCACDPEYTLESDGRTCKVTGSENPLLVVASRDKIIVDNITAHTHN
LYSLVQDVSFVVALDFDSVTGRVFWSDLLQGKTWSVFQNGTDKRVVHDSG
LSVTEMIAVDWIGRNLYWTDYALETIEVSKIDGSHRTVLISKNVTKPRGL
ALDPRMGDNVMFWSDWGHHPRIERASMDGTMRTVIVQEKIYWPCGLSIDY
PNRLIYFMDAYLDYIEFCDYDGHNRRQVIASDLVLHHPHALTLFEDFVYW
TDRGTRQVMQANKWHGGNQSVVMYSVHQPLGITAIHPSRQPPSRNPCASA
SCSHLCLLSAQAPRHYSCACPSGWNLSDDSVNCVRGDQPFLMSVRDNIIF
GISLDPEVKSNDAMVPISGIQHGYDVEFDDSEQFIYWVENPGEIHRVKTD
GSNRTVFAPLSLLGSSLGLALDWVSRNIYYTTPASRSIEVLTLKGDTRYG
KTLIANDGTPLGVGFPVGIAVDPARGKLYWSDHGTDSGVPAKIASANMDG
TSLKILFTGNLQHLEVVTLDIQEQKLYWAVTSRGVIERGNVDGTERMILV
HHLAHPWGLVVYGSFLYYSDEQYEVIERVDKSSGNNKVVLRDNVPYLRGL
RVYHRRNAADSSNGCSNNPNACQQICLPVPGGMFSCACASGFKLSPDGRS
CSPYNSFMVVSMLPAVRGFSLELSDHSEAMVPVAGQGRNVLHADVDVANG
FIYWCDFSSSVRSSNGIRRIKPDGSNFTNVVTYGIGANGIRGVALDWAAG
NLYFTNAFVYETLIEVLRINTTYRRVLLKVSVDMPRHIIVDPKHRYLFWA
DYGQKPKIERSFLDCTNRTVLVSEGIVTPRGLAMDHDTGYIYWVDDSLDL
IARIHLDGGESQVVRYGSRYPTPYGITVFGESIIWVDRNLKKVFQASKQP
GNTDPPVVIRDKINLLRDVTIFDEHAQPLSPAELNNNPCLQSNGGCSHFC
FALPELPTPRCGCAFGTLGNDGKSCATSQEDFLIYSLNNSLRSLHFDPRD
HSLPFQVISVAGTAIALDYDRRNNRIFFTQKLNSLRGQISYVSLYSGSSS
PTVLLSNIGVTDGIAFDWINRRIYYSDFSNQTINSMAEDGSNRAVIARVS
KPRAIVLDPCRGYMYWTDWGTNAKIERATLGGNFRVPIVNTSLVWPNGLA
LDLETDLLYWADASLQKIERSTLTGTNREVVVSTAFHSFGLTVYGQYIYW
TDLYTRKIYRANKYDGSDLVAMTTRLPTQPSGISTVVKTQRQQCSNPCDQ
FNGGCSHICAPGPNGAECQCPHEGNWYLANDNKYCVVDTGTRCNQLQFTC
LNGHCINQDWKCDNDNDCGDGSDELPTVCAFHTCRSTAFTCGNGRCVPYH
YRCDYYNDCGDNSDEAGC

Ligand information

>8jxe Chain G (length=5) Species: 10116 (Rattus norvegicus) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

AEEAA

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8jxe Cryo-EM structures elucidate the multiligand receptor nature of megalin.
Resolution	3.2 Å
Binding residue (original residue number in PDB)	L2071 N2097 F2115 N2146 R2149 R2296
Binding residue (residue number reindexed from 1)	L763 N789 F807 N838 R841 R988

External links

PDB	RCSB:8jxe, PDBe:8jxe, PDBj:8jxe
PDBsum	8jxe
PubMed	38771880
UniProt	P98158\|LRP2_RAT Low-density lipoprotein receptor-related protein 2 (Gene Name=Lrp2)

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