Structure of PDB 8jx8 Chain B Binding Site BS03

Receptor Information

>8jx8 Chain B (length=1434) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

TQPFHCPSTQWQCPGYSTCINLSALCDGVFDCPNGTDESPLCNQDSCSHF
NGGCTHQCMQGPFGATCLCPLGYQLANDTKTCEDINECDIPGFCSQHCVN
MRGSFRCACDPEYTLESDGRTCKVTGSENPLLVVASRDKIIVDNITAHTH
NLYSLVQDVSFVVALDFDSVTGRVFWSDLLQGKTWSVFQNGTDKRVVHDS
GLSVTEMIAVDWIGRNLYWTDYALETIEVSKIDGSHRTVLISKNVTKPRG
LALDPRMGDNVMFWSDWGHHPRIERASMDGTMRTVIVQEKIYWPCGLSID
YPNRLIYFMDAYLDYIEFCDYDGHNRRQVIASDLVLHHPHALTLFEDFVY
WTDRGTRQVMQANKWHGGNQSVVMYSVHQPLGITAIHPSRQPPSRNPCAS
ASCSHLCLLSAQAPRHYSCACPSGWNLSDDSVNCVRGDQPFLMSVRDNII
FGISLDPEVKSNDAMVPISGIQHGYDVEFDDSEQFIYWVENPGEIHRVKT
DGSNRTVFAPLSLLGSSLGLALDWVSRNIYYTTPASRSIEVLTLKGDTRY
GKTLIANDGTPLGVGFPVGIAVDPARGKLYWSDHGTDSGVPAKIASANMD
GTSLKILFTGNLQHLEVVTLDIQEQKLYWAVTSRGVIERGNVDGTERMIL
VHHLAHPWGLVVYGSFLYYSDEQYEVIERVDKSSGNNKVVLRDNVPYLRG
LRVYHRRNAADSSNGCSNNPNACQQICLPVPGGMFSCACASGFKLSPDGR
SCSPYNSFMVVSMLPAVRGFSLELSDHSEAMVPVAGQGRNVLHADVDVAN
GFIYWCDFSSSVRSSNGIRRIKPDGSNFTNVVTYGIGANGIRGVALDWAA
GNLYFTNAFVYETLIEVLRINTTYRRVLLKVSVDMPRHIIVDPKHRYLFW
ADYGQKPKIERSFLDCTNRTVLVSEGIVTPRGLAMDHDTGYIYWVDDSLD
LIARIHLDGGESQVVRYGSRYPTPYGITVFGESIIWVDRNLKKVFQASKQ
PGNTDPPVVIRDKINLLRDVTIFDEHAQPLSPAELNNNPCLQSNGGCSHF
CFALPELPTPRCGCAFGTLGNDGKSCATSQEDFLIYSLNNSLRSLHFDPR
DHSLPFQVISVAGTAIALDYDRRNNRIFFTQKLNSLRGQISYVSLYSGSS
SPTVLLSNIGVTDGIAFDWINRRIYYSDFSNQTINSMAEDGSNRAVIARV
SKPRAIVLDPCRGYMYWTDWGTNAKIERATLGGNFRVPIVNTSLVWPNGL
ALDLETDLLYWADASLQKIERSTLTGTNREVVVSTAFHSFGLTVYGQYIY
WTDLYTRKIYRANKYDGSDLVAMTTRLPTQPSGISTVVKTQRQQCSNPCD
QFNGGCSHICAPGPNGAECQCPHEGNWYLANDNKYCVVDTGTRCNQLQFT
CLNGHCINQDWKCDNDNDCGDGSDELPTVCAFHT

Ligand information

>8jx8 Chain G (length=5) Species: 10116 (Rattus norvegicus) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

AEEAA

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8jx8 Cryo-EM structures elucidate the multiligand receptor nature of megalin.
Resolution	3.3 Å
Binding residue (original residue number in PDB)	N2097 F2115 R2149 R2194 Y2210 R2296 R2325
Binding residue (residue number reindexed from 1)	N790 F808 R842 R887 Y903 R989 R1018

External links

PDB	RCSB:8jx8, PDBe:8jx8, PDBj:8jx8
PDBsum	8jx8
PubMed	38771880
UniProt	P98158\|LRP2_RAT Low-density lipoprotein receptor-related protein 2 (Gene Name=Lrp2)

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