Structure of PDB 8j9w Chain B Binding Site BS03

Receptor Information
>8j9w Chain B (length=775) Species: 10497 (African swine fever virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
YTRARNAGGKRAQDCMLLAAEGDSALSLLRTGLTLGKSNPSGPSFDFCGM
ISLGGVIMNACKKVTNITTDSGETIMVRNEQLTNNKVLQGIVQVLGLDFN
CHYKTQEERAKLRYGCIVACVDQDLDGCGKILGLLLAYFHLFWPQLIIHG
FVKRLLTPLIRVYEKGKTMPVEFYYEQEFDAWAKKQTSLVNHTVKYYKGL
AAHDTHEVKSMFKHFDNMVYTFTLDDSAKELFHIYFGGESELRKRELCTG
VVPLTETQTQSIHSVRRIPCSLHLQVDTKAYKLDAIERQIPNFLDGMTRA
RRKILAGGVKCFASNNRERKVFQFGGYVADHMFYHHGDMSLNTSIIKAAQ
YYPGSSHLYPVFIGIGSFGSRHLGGKDAGSPRYISVQLASEFIKTMFPAE
DSWLLPYVFEDGQRAEPEYYVPVLPLAIMEYGANPSEGWKYTTWARQLED
ILALVRAYVDKDNPKHELLHYAIKHKITILPLRPSNYNFKGHLKRFGQYY
YSYGTYDISEQRNIITITELPLRVPTVAYIESIKKSSNRMTFIEEIIDYS
SSETIEILVKLKPNSLNRIVEEFKETEEQDSIENFLRLRNCLHSHLNFVK
PKGGIIEFNSYYEILYAWLPYRRELYQKRLMREHAVLKLRIIMETAIVRY
INESAELNLSHYEDEKEASRILSEHGFPPLNHTLIISPEFASIEELNQKA
LQGCYTYILSLQARELLIAAKTRRVEKIKKMQARLDKVEQLLQESPFPGA
SVWLEEIDAVEKAIIKGRNTQWKFH
Ligand information
Receptor-Ligand Complex Structure
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PDB8j9w Cryo-EM structure of the African swine fever virus topoisomerase 2 complexed with Cut02bDNA and etoposide (EDI-2)
Resolution2.76 Å
Binding residue
(original residue number in PDB)		M475 N476 K479 K480 Q498 S657 P852 S853 E854 G855 W856 K857 H1010
Binding residue
(residue number reindexed from 1)		M58 N59 K62 K63 Q81 S240 P435 S436 E437 G438 W439 K440 H593
Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003916 DNA topoisomerase activity
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
GO:0046872 metal ion binding
Biological Process
GO:0000819 sister chromatid segregation
GO:0006259 DNA metabolic process
GO:0006265 DNA topological change
Cellular Component
GO:0030430 host cell cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8j9w, PDBe:8j9w, PDBj:8j9w
PDBsum8j9w
PubMed38418525
UniProtQ00942|TOP2_ASFB7 DNA topoisomerase 2 (Gene Name=TOP)

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