Structure of PDB 8j12 Chain B Binding Site BS03

Receptor Information
>8j12 Chain B (length=385) Species: 1765684 (Sulfoacidibacillus thermotolerans) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MIKVYRYEIVKPLDLDWKEFGTILRQLQQETRFALNKATQLAWEWMGFSS
DYKDNLGYTNVHGYAYHTIKTKAYRLNSGNLSQTIKRATDRFKAYQKEIL
RGDMSIPSYKRDIPLDLIKENISVNRMNHGDYIASLSLLSNPAKQEMNVK
RKISVIIIVRGAGKTIMDRILSGEYQVSASQIIHDDRKNKWYLNISYDFE
PQTRVLDLNKIMGIDLGVAVAVYMAFQHTPARYKLEGGEIENFRRQVESR
RISMLRQKPIEQLRDKIANFRDTTNHRYSRYIVDMAIKEGCGTIQMEDLD
IGSRFLQNWTYYDLQQKIIYKAEEAGIKVIKIDPQYTSQRCSECGNIDGQ
AIFKCRACGYEANADYNAARNIAIPNIDKIIAESI
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8j12 Chain B Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8j12 Minimal and most efficient genome editing Cas enzyme
Resolution3.08 Å
Binding residue
(original residue number in PDB)		C372 C375 C391 C394
Binding residue
(residue number reindexed from 1)		C341 C344 C355 C358
Annotation score4
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:8j12, PDBe:8j12, PDBj:8j12
PDBsum8j12
PubMed
UniProtA0A2U3D0N8|CS12F_SULT2 CRISPR-associated endodeoxyribonuclease Cas12f1 (Gene Name=cas12f1)

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