Structure of PDB 8j0k Chain B Binding Site BS03

Receptor Information
>8j0k Chain B (length=209) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VVNPNEVFCSVPGRLSLLSSTSKYKVTVAEVQRRLSPPECLNASLLGGVL
RRAKSKNGGRSLREKLDKIGLNLPAGRRKAANVTLLTSLVEGEAVHLARD
FGYVCETEFPAKAVAEFLNRQHSDPNEQVTRKNMLLATKQICKEFTDLLA
QDRSPLGNSRPNPILEPGIQSCLTHFNLISHGFGSPAVCAAVTALQNYLT
EALKAMDKM
Ligand information
Ligand IDPG3
InChIInChI=1S/C4H11N3O/c5-4(6)7-2-1-3-8/h8H,1-3H2,(H4,5,6,7)/p+1
InChIKeyJDXXTKLHHZMVIO-UHFFFAOYSA-O
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(CNC(=[NH2+])N)CO
CACTVS 3.341NC(=[NH2+])NCCCO
ACDLabs 10.04OCCCNC(=[NH2+])\N
FormulaC4 H12 N3 O
NameGUANIDINE-3-PROPANOL
ChEMBL
DrugBankDB03637
ZINC
PDB chain8j0k Chain B Residue 503 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8j0k Structural basis for specific DNA sequence motif recognition by the TFAP2 transcription factors.
Resolution2.1 Å
Binding residue
(original residue number in PDB)		R302 G305 P389 A393 T396
Binding residue
(residue number reindexed from 1)		R99 G102 P186 A190 T193
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8j0k, PDBe:8j0k, PDBj:8j0k
PDBsum8j0k
PubMed37409559
UniProtP05549|AP2A_HUMAN Transcription factor AP-2-alpha (Gene Name=TFAP2A)

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