Structure of PDB 8i3a Chain B Binding Site BS03

Receptor Information
>8i3a Chain B (length=562) Species: 3702 (Arabidopsis thaliana) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SSSCFPITLKFVDVCYRVKIHEERTILSGVTGMISPGEFMAVLGPSGSGK
STLLNAVAGRLHGSNLTGKILINDGKITKQTLKRTGFVAQDDLLYPHLTV
RETLVFVALLRLPRSLTRDVKLRAAESVISELGLTKCENTVVGNTFIRGI
SGGERKRVSIAHELLINPSLLVLDQPTSGLDATAALRLVQTLAGLAHGKG
KTVVTSIHQPSSRVFQMFDTVLLLSEGKCLFVGKGRDAMAYFESVGFSPA
FPMNPADFLLDLANGVCQTPNVRQTLVTAYDTLLAPQVKTCIEVSHFITT
CIATWFSQLCILLHRLLKERRHESFDLLRIFQVVAASILCGLMWWHSDYR
DVHDRLGLLFFISIFWGVLPSFNAVFTFPQERAIFTRERASGMYTLSSYF
MAHVLGSLSMELVLPASFLTFTYWMVYLRPGIVPFLLTLSVLLLYVLASQ
GLGLALGAAIMDAKKASTIVTVTMLAFVLTGGYYVNKVPSGMVWMKYVST
TFYCYRLLVAIQYGSGEEILRMLFVEEEVIGDVGMWTSVGVLFLMFFGYR
VLAYLALRRIKH
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain8i3a Chain B Residue 701 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8i3a Cryo-EM structure and molecular mechanism of abscisic acid transporter ABCG25.
Resolution3.04 Å
Binding residue
(original residue number in PDB)		S108 D231 Q232
Binding residue
(residue number reindexed from 1)		S51 D174 Q175
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0015562 efflux transmembrane transporter activity
GO:0016887 ATP hydrolysis activity
GO:0042626 ATPase-coupled transmembrane transporter activity
GO:0140359 ABC-type transporter activity
Biological Process
GO:0009408 response to heat
GO:0009409 response to cold
GO:0009737 response to abscisic acid
GO:0009738 abscisic acid-activated signaling pathway
GO:0010496 intercellular transport
GO:0048581 negative regulation of post-embryonic development
GO:0055085 transmembrane transport
GO:0080168 abscisic acid transport
GO:0140352 export from cell
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8i3a, PDBe:8i3a, PDBj:8i3a
PDBsum8i3a
PubMed37666961
UniProtQ84TH5|AB25G_ARATH ABC transporter G family member 25 (Gene Name=ABCG25)

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