Structure of PDB 8h0w Chain B Binding Site BS03

Receptor Information
>8h0w Chain B (length=1161) Species: 460519 (Komagataella phaffii) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DDTITTEDCWTVISAFFEEKGLVSQQLDSFDEFMETSIQDLVWEEPRLIL
DQPAQHTNEKDNINKRYEIRFGKIYLSRPTMTEADGTTHAMFPQEARLRN
LTYSSPVYLDMEKSMFTSIDGNKVHIGKVPIMLRSKFCSLRTLDEVDLYK
MKECPYDMGGYFVINGSEKVLIAQERSAANIVQVFKKAAPSPISHVAEIR
SALEKGSRLISTMQIKLYGREDKGTGRTIKATLPYVKQDIPIVIVFRALG
VVPDGEILQHICYDENDWQMLEMLKPCIEEGFVIQDKEVALDFIGRRGSA
ALGIRREKRIQYAKDILQKELLPHITQEEGFETRKTFFLGYMVNRLLLCA
LERKDQDDRDHFGKKRLDLAGPLLANLFRILFRKLTREIYRYMQRCIETD
RDFNLNLAVKSTTITSGLKYSLATGNWGEQKKAMSSRAGVSQVLNRYTYS
STLSHLRRTNTPIGRDGKLAKPRQLHNTHWGLVCPAETPEGQACGLVKNL
SLLSGISIGSPSEPIINFLEEWGMEPLEDYDPAQHTKSTRIFVNGVWTGI
HRDPSMLVSTMRDLRRSGAISPEVSIIRDIREREFKIFTDVGRVYRPLFI
VEDDESKDNKGELRITKEHIRKIQQGYDDDVYGWSSLVTSGVIEYVDGEE
EETIMIAMTPEDLQTRSLNDTAKRIKPEMSTSSHHTFTHCEIHPSMILGV
AASIIPFPDHNQSPRNTYQSAMGKQAMGVFLTNYNVRMDTMANILYYPQK
PLAKTQAMEYLKFRELPAGQNAIVAIACYSGYNQEDSMIMNQSSIDRGLF
RSLFFRSYMDQEKRFGISIVEEFEKPTRATTLRLKHGTYEKLDEDGLIAP
GVRVSGDDIIIGKTTPIPPYHTKRDASTPLRSTENGIVDQVLLTTNQEGL
KFVKVRMRTTKVPQIGDKFASRHGQKGTIGVTYRHEDMPFSAEGIVPDLI
INPHAIPSRMTVAHLIECLLSKVGSIRGYEGDATPFTDLTVDAVSNLLRD
NGYQSRGFEVMYNGHTGKKLMAQVFFGPTYYQRLRHMVDDKIHARARGPV
QVLTRQPVEGRSRDGGLRFGEMERDCMIAHGAAGFLKERLMEASDAFRVH
VCGICGLMSVIANLKKNQFECRSCKNKTNIYQLHIPYAAKLLFQELMAMN
IAPRLYTERSG
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8h0w Chain B Residue 1301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8h0w Structural basis of RNA polymerase II transcription on the chromatosome containing linker histone H1.
Resolution4.6 Å
Binding residue
(original residue number in PDB)		C1163 C1166 C1182 C1185
Binding residue
(residue number reindexed from 1)		C1102 C1105 C1121 C1124
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0001055 RNA polymerase II activity
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0032549 ribonucleoside binding
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006366 transcription by RNA polymerase II
GO:0006367 transcription initiation at RNA polymerase II promoter
GO:0140727 siRNA-mediated pericentric heterochromatin formation
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005654 nucleoplasm
GO:0005665 RNA polymerase II, core complex
GO:0005721 pericentric heterochromatin

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8h0w, PDBe:8h0w, PDBj:8h0w
PDBsum8h0w
PubMed36435862
UniProtC4QZQ7

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