Structure of PDB 8gbq Chain B Binding Site BS03

Receptor Information
>8gbq Chain B (length=93) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SFDCAVCLEVLHQPVRTRCGHVFCRSCIATSLKNNKWTCPYCRAYLPSEG
VPATDVAKRMKSEYKNCAECDTLVCLSEMRAHIRTCQKYIDKY
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8gbq Chain B Residue 204 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8gbq Zinc finger 1 of the RING E3 ligase, RNF125, interacts with the E2 to enhance ubiquitylation.
Resolution1.74 Å
Binding residue
(original residue number in PDB)		C100 C103 H115 C119
Binding residue
(residue number reindexed from 1)		C67 C70 H82 C86
Annotation score4
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
External links
PDB RCSB:8gbq, PDBe:8gbq, PDBj:8gbq
PDBsum8gbq
PubMed37541247
UniProtQ96EQ8|RN125_HUMAN E3 ubiquitin-protein ligase RNF125 (Gene Name=RNF125)

[Back to BioLiP]