Structure of PDB 8g9o Chain B Binding Site BS03

Receptor Information

>8g9o Chain B (length=186) Species: 8355 (Xenopus laevis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

ISLEQIDGFAAKSFPLCMRQLHKSLRENHHLRHGGRMQYGLFLKGIGLTL
EQALQFWRLEFTKGKVDSEKFDKVYAYSIRHNYGKEGKRTDYTPYSCMKV
ILSNPPSQGDYHGCPFRHSDPELLKQKLQSFKVPSSGINQILELVKGMHY
QLACQKYFELTHSVDDCGFSLNHPNQYFAESQKLLT

Ligand information

InChI=1S/4Fe.4S

LJBDFODJNLIPKO-UHFFFAOYSA-N

SMILES

Software	SMILES
OpenEye OEToolkits 2.0.7	[S]12[Fe]3[S]4[Fe]1[S]5[Fe]2[S]3[Fe]45
CACTVS 3.385	S1[Fe]S[Fe]1.S2[Fe]S[Fe]2

Formula

Fe4 S4

Name

IRON/SULFUR CLUSTER

ChEMBL

DrugBank

ZINC

PDB chain

8g9o Chain B Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8g9o A mechanistic model of primer synthesis from catalytic structures of DNA polymerase alpha-primase.
Resolution	4.4 Å
Binding residue (original residue number in PDB)	P291 C293 C373 C390 C430
Binding residue (residue number reindexed from 1)	P15 C17 C97 C114 C154
Annotation score	4

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0046872	metal ion binding
GO:0051539	4 iron, 4 sulfur cluster binding

	Biological Process
GO:0006260	DNA replication
GO:0006261	DNA-templated DNA replication
GO:0006269	DNA replication, synthesis of primer
GO:0006270	DNA replication initiation

	Cellular Component
GO:0005658	alpha DNA polymerase:primase complex
GO:1990077	primosome complex

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Molecular Function

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Cellular Component

External links

PDB	RCSB:8g9o, PDBe:8g9o, PDBj:8g9o
PDBsum	8g9o
PubMed	38491139
UniProt	A0A1L8G3G3

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