Structure of PDB 8g8v Chain B Binding Site BS03

Receptor Information
>8g8v Chain B (length=254) Species: 28450 (Burkholderia pseudomallei) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QSTVDTRQMPIQRVGVRAVRHPLTVRTAEGETQATVGTWNLDVHLPADQK
GTHMSRFVALLEERGGPLTADAFRTMLATMLEKLEARAGRIEVSFPYFVN
KTAPVSGVRSLLDYEVTLTGDVRDGLTRVFAKVLVPVTSLCPCSKKISQY
GAHNQRSHVTIDAELAADVPVEDLIRIAEEEASCELWGLLKRPDEKFVTE
RAYENPKFVEDLVRDVARRLDADERIVAYVLEAENFESIHNHSAYALIER
DKRR
Ligand information
Ligand IDSO3
InChIInChI=1S/H2O3S/c1-4(2)3/h(H2,1,2,3)/p-2
InChIKeyLSNNMFCWUKXFEE-UHFFFAOYSA-L
SMILES
SoftwareSMILES
CACTVS 3.341[O-][S]([O-])=O
OpenEye OEToolkits 1.5.0[O-]S(=O)[O-]
ACDLabs 10.04[O-]S([O-])=O
FormulaO3 S
NameSULFITE ION
ChEMBL
DrugBank
ZINC
PDB chain8g8v Chain B Residue 307 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8g8v Combatting melioidosis with chemical synthetic lethality
Resolution2.03 Å
Binding residue
(original residue number in PDB)		T132 D175
Binding residue
(residue number reindexed from 1)		T119 D162
Annotation score1
Enzymatic activity
Enzyme Commision number 3.5.4.16: GTP cyclohydrolase I.
Gene Ontology
Molecular Function
GO:0003933 GTP cyclohydrolase activity
GO:0003934 GTP cyclohydrolase I activity
GO:0016787 hydrolase activity
Biological Process
GO:0046654 tetrahydrofolate biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:8g8v, PDBe:8g8v, PDBj:8g8v
PDBsum8g8v
PubMed
UniProtQ63JF5|GCH4_BURPS GTP cyclohydrolase FolE2 (Gene Name=folE2)

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